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DNA damage signaling recruits the Rtt107-Slx4 scaffolds via Dpb11 to mediate re…

Ohouo(Patrice Y),Bastos de Oliveira(Francisc… Mol Cell 2010-08-20

...Slx4-Rtt107 to regulate replication stress response. Dissection of the molecular basis of the interaction reveals that S...

Loss of H3 K79 trimethylation leads to suppression of Rtt107-dependent DNA dama…

Lévesque(Nancy),Leung(Grace P),Fok(Alexandra… J Biol Chem 2010-11-30

...Slx4 during DNA damage repair. Here, we report that the sensitivity to DNA-damaging agents of rtt107Δ and slx4Δ mutants ...

Specific pathways prevent duplication-mediated genome rearrangements.

Putnam(Christopher D),Hayes(Tikvah K),Kolodn… Nature 2009-09-23

...SLX4, SLX5, MSH2, MSH6, RAD10 and the DNA replication stress checkpoint requiring MRC1 and TOF1, were highly specific fo...

A tale of tails: insights into the coordination of 3' end processing during hom…

Lyndaker(Amy M),Alani(Eric) Bioessays 2009-09-04

...Slx4, and the newly identified Saw1 protein. Together, this new work provides a model for how Rad1-Rad10-dependent end p...

Coordination of structure-specific nucleases by human SLX4/BTBD12 is required f…

Muñoz(Ivan M),Hain(Karolina),Déclais(Anne-Cé… Mol Cell 2009-09-25

...Slx4 interacts with the structure-specific endonuclease Slx1 to ensure completion of ribosomal DNA replication. Slx4 als...

Drosophila MUS312 and the vertebrate ortholog BTBD12 interact with DNA structur…

Andersen(Sabrina L),Bergstralh(Daniel T),Koh… Mol Cell 2009-09-25

...Slx4 helped identify a conserved interaction with a second structure-specific endonuclease, SLX1. Genetic and biochemica...

Breaking up just got easier to do.

Klein(Hannah L),Symington(Lorraine S) Cell 2009-07-27

The SLX4 protein functions as a platform for catalytic subunits of structure-specific endonucleases. Findings reported i...

Mammalian BTBD12/SLX4 assembles a Holliday junction resolvase and is required f…

Svendsen(Jennifer M),Smogorzewska(Agata),Sow… Cell 2009-07-27

...Slx4p and D. melanogaster MUS312. Human SLX4 forms a multiprotein complex with the ERCC4(XPF)-ERCC1, MUS81-EME1, and SLX...

Human SLX4 is a Holliday junction resolvase subunit that binds multiple DNA rep…

Fekairi(Samira),Scaglione(Sarah),Chahwan(Cha… Cell 2009-07-27

...Slx4 has received particular attention with the finding that Slx4 has Slx1-independent key functions in genome maintenan...

Control of genome stability by SLX protein complexes.

Rouse(John) Biochem Soc Trans 2009-09-29

...Slx4 is essential for repair of DSBs by Rad1-Rad10, but is not required for repair of UV damage. Slx4 also promotes cell...

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