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TP53 BRCA1 CRISPR single-cell cancer

Dietel(M),Jöhrens(K),Laffert(M V),Hummel(M... Cancer Gene Ther 2016-07-12

...BRCA1/2 come up and proven as a true challenge for routine diagnostics because of the genes' special structure and hot-s...

Woolery(Kamisha T),Mohamed(Mai),Linger(Reb... Biomed Res Int 2016-06-09

Familial history remains the strongest risk factor for developing ovarian cancer (OC) and is associated with germline BR...

La Verde(Nicla),Corsi(Fabio),Moretti(Anna)... Tumori 2016-07-11

...BRCA1/BRCA2 mutation. After genetic test results, the available options for treatment/surveillance were discussed by a m...

Peng(Jingtao),Ma(Jian),Li(Weiguo),Mo(Ren),... Cancer Lett 2016-02-01

...BRCA1-associated protein-1 (BAP1) was identified as one of the most frequently mutated genes in ccRCC, suggesting that B...

Duru(Nadire),Gernapudi(Ramkishore),Zhang(Y... Cancer Lett 2016-02-01

...BRCA1-dependent activation of NRF2 through the inhibition of KEAP1 function, promoting the nuclear accumulation of NRF2,...

Belotte(Jimmy),Fletcher(Nicole M),Saed(Moh... PLoS One 2016-05-17

...BRCA1/2 negative (n = 53), high-risk BRCA1/2 positive (n = 23) and ovarian cancer cases (n = 49). DNA was subjected to T...

Sanford(Rachel A),Song(Juhee),Gutierrez-Ba... Cancer 2016-02-01

...BRCA1/2 mutation, whereas in the HR-low-positive group, 30 of 76 (39.5%) had a BRCA1/2 mutation. In multivariate analysi...

Pisanic(Thomas R),Athamanolap(Pornpat),Poh... Nucleic Acids Res 2016-06-21

...BRCA1 gene-promoter loci in liquid biopsies obtained from patients in association with non-small cell lung cancer (NSCLC...

Lee(Cindy),Banerjee(Tapahsama),Gillespie(J... Hum Mutat 2016-08-19

...BRCA1 and is included on clinical gene panels for testing for susceptibility to HBOC. Like BRCA1, it is required for hom...

Biesma(Hedde D),Schouten(Philip C),Lacle(M... Genes Chromosomes Cancer 2016-07-22

...BRCA1-like. One patient (1%) was only BRCA1-like; the remaining 53 (77%) patients were classified as non-BRCA-like. BRCA...

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