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TP53 BRCA1 CRISPR single-cell cancer

Raymond(Anne-Aurélie),Benhamouche(Samira),... PLoS One 2016-01-15

...BRCA1 (3-fold) and 53BP1 foci (7.5 fold). Depletion of Reptin reduced these values by 62 and 48%, respectively. These de...

Apostoli(Anthony J),Roche(Jennifer M),Schn... Mol Cancer 2016-02-04

...BRCA1 and decreased VEGF and COX-2 protein expression levels in breast tumours; whereas, surprisingly DMBA + ROSI-treate...

Dacheva(Daniela),Dodova(Rumyana),Popov(Iva... Mol Diagn Ther 2016-01-18

Pathogenic mutations in BRCA1/2 tumor suppressor genes increase the lifetime risk for developing breast and ovarian canc...

Zhu(Qianzheng),Sharma(Nidhi),He(Jinshan),W... Cell Cycle 2016-02-23

...BRCA1 and 53BP1. Here, we report USP7 deubiquitinase regulates the stability of RNF168. We showed that USP7 disruption i...

Frankum(Jessica),Moudry(Pavel),Brough(Rach... Oncotarget 2016-02-29

...BRCA1 or BRCA2 mutations. By identifying novel predictive biomarkers of tumour cell sensitivity to olaparib, it is possi...

Kang(Eunyoung),Seong(Moon-Woo),Park(Sue K)... Breast Cancer Res Treat 2016-01-25

The Korean Hereditary Breast Cancer (KOHBRA) study was established to evaluate the prevalence and spectrum of BRCA1/2 mu...

Zhu(Qing),Han(Su-Xia),Zhou(Cong-Ya),Cai(Me... Oncotarget 2016-02-29

...BRCA1/BRCA2 in breast cancer.,Autoantibody frequency to PARP1, BRCA1, and BRCA2 in cancer varied from 0% to 50%. When th...

El Saghir(Nagi S),Zgheib(Nathalie K),Assi(... Oncologist 2016-04-25

...BRCA1 and BRCA2 were sequenced from peripheral blood DNA. All patients were tested for BRCA1 rearrangements using multip...

Aktas(Bertal H),Bordelois(Paula),Peker(Sel... Oncotarget 2016-01-15

...BRCA1. The BRCA1 gene produces two transcripts, mRNAa and mRNAb. mRNAb, present in breast cancer but not in normal mamma...

Ip(Laura R H),Poulogiannis(George),Viciano... Oncotarget 2016-03-14

...BRCA1, in GST pulldown and 293T overexpression assays, and INPP4B loss affects BRCA1, ATM and ATR protein stability resu...

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