...MSH2 recognizes DNA sequence heterology and enforces anti-recombination in yeast. This raises the possibility that Msh2 ...
...MSH2-MSH6) and MutLα (MLH1-PMS2) complexes, recognizes O6-meG: thymine mispairs generated during replication and initiat...
...MSH2 confers the greatest urothelial cancer risk among the 4 MMR genes. MMR-deficient tumors show marked sensitivity to ...
...Msh2), implicated in the DNA mismatch repair pathway, is the most upregulated gene in Krt15+ esophageal stem cells compa...
...MSH2) and the PRS were independently associated with PCa risk (all p<0.001) in UKB. Compared with binary models, GenProb...
...MSH2 than MSH6/PMS2 carriers: MLH1 (AADR 5.1%, CRCDR 5.1%) and MSH2/EPCAM (AADR 6.3%, CRCDR 4.7%) versus MSH6 (AADR 3.5%...
...MSH2:MSH6) and MutSβ (MSH2:MSH3) MMR recognition complexes. Pharmacological or genetic depletion of the class III PI3-ki...
...MSH2 variants (path_MSH2), as for other LS non-endodermal tumors. Our second hypothesis, which was derived from findings...
...MSH2, MSH6, PMS2, EPCAM) that results in genomic microsatellite instability (MSI-high). However, microsatellite-stable (...
...MSH2), MutS homolog 6 (MSH6), and PMS1 homolog 2 (PMS2), in CRC and normal tissues using the Tumor, Normal and Metastati...
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