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The checkpoint clamp activates Mec1 kinase during initiation of the DNA damage …

Majka(Jerzy),Niedziela-Majka(Anita),Burgers(… Mol Cell 2007-01-25

...Rad17/Mec3/Ddc1 (the 9-1-1 complex in human) and its loader Rad24-RFC are also essential components of this signal trans...

DNA-damage control: Claspin destruction turns off the checkpoint.

Gewurz(Benjamin E),Harper(J Wade) Curr Biol 2007-01-03

...Rad17 phosphorylation and the ubiquitin proteasome pathway in Chk1 signaling.

Two distinct surveillance mechanisms monitor meiotic chromosome metabolism in b…

Wu(Hsin-Yen),Burgess(Sean M) Curr Biol 2007-03-05

...Rad17, a component of a PCNA clamp-like complex, and Pch2, a putative AAA-ATPase . We show that two genetically separabl...

Cyclin and cyclin-dependent kinase substrate requirements for preventing rerepl…

Ikui(Amy E),Archambault(Vincent),Drapkin(Ben… Genetics 2007-10-15

...Rad17 provide additional mechanisms that maintain viability and also prevent further rereplication, and this probably co...

Biochemical characterization of DNA damage checkpoint complexes: clamp loader a…

Ellison(Viola),Stillman(Bruce) PLoS Biol 2006-01-26

...Rad17, Rad9, Hus1, Rad1, and Rfc-2, Rfc-3, Rfc-4, and Rfc-5. The heteropentamer replication factor C (RFC) loads during ...

Activation of S phase checkpoint by cigarette smoke extract in Schizosaccharomy…

Chaudhuri(Santanu Pal),Sundaram(Geetanjali),… Yeast 2006-01-05

...Rad17, Rad1, Hus1 and Cds1 play key roles in this process, as evidenced by cell survival and biochemical analysis, altho...

DNA damage checkpoints in mammals.

Niida(Hiroyuki),Nakanishi(Makoto) Mutagenesis 2006-04-11

...Rad17-RFC complex, in the detection of DNA damage and transduction of signals to ATM, ATR, Chk1 and Chk2 kinases. Chk1 a...

Spatial organization of the mammalian genome surveillance machinery in response…

Bekker-Jensen(Simon),Lukas(Claudia),Kitagawa… J Cell Biol 2006-06-09

...Rad17 and -9) accumulate in subchromatin microcompartments delineated by single-stranded DNA (ssDNA). BRCA1 and the Mre1...

Mammalian Rad9 plays a role in telomere stability, S- and G2-phase-specific cel…

Pandita(Raj K),Sharma(Girdhar G),Laszlo(Andr… Mol Cell Biol 2006-04-04

...rad17+, rad26+, and hus1+) play crucial roles in sensing changes in DNA structure, and several function in the maintenan...

Mnd1/Hop2 facilitates Dmc1-dependent interhomolog crossover formation in meiosi…

Henry(Jill M),Camahort(Raymond),Rice(Douglas… Mol Cell Biol 2006-05-03

...rad17 double mutants are able to carry out crossover recombination. Interestingly, noncrossover recombination is absent,...

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