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MERIT40 Is an Akt Substrate that Promotes Resolution of DNA Damage Induced by...

Brown(Kristin K),Montaser-Kouhsari(Laleh),... Cell Rep 2016-04-12

...BRCA1-A DNA damage repair complex, as an Akt substrate that is phosphorylated following doxorubicin treatment. MERIT40 p...

Breast and ovarian cancer predisposition due to de novo BRCA1 and BRCA2 mutat...

Golmard(L),Delnatte(C),Laugé(A),Moncoutier... Oncogene 2016-07-25

...BRCA1/2 mutations have been reported to date and the BRCA1/2 de novo mutation rate remains unknown. The present study wa...

High prevalence of BRCA1 stop mutation c.4183C>T in the Tyrolean population: ...

Pölsler(Laura),Fiegl(Heidi),Wimmer(Kathari... Eur J Hum Genet 2016-10-07

...BRCA1 and BRCA2 testing was performed in a routine diagnostic setting. The prevalence of the BRCA1 stop mutation c.4183C...

Tamoxifen and risk of contralateral breast cancer among women with inherited ...

Xu(Lingyun),Zhao(Yansheng),Chen(Zhiqiang),... Breast Cancer 2016-04-25

...BRCA1/2 mutation carriers (summary RR = 0.56, 95 % CI = 0.41-0.76). Similar findings were observed in BRCA1 mutation car...

Assessing absolute changes in breast cancer risk due to modifiable risk factors.

Quante(Anne S),Herz(Julia),Whittemore(Alic... Breast Cancer Res Treat 2016-03-04

...BRCA1 mutation, compared to 4.5 % for a mutation carrier with three such relatives. This contrast illustrates the value ...

Comparative proteomic analysis of primordial follicles from ovaries of immatu...

Govindaraj(Vijayakumar),Rao(A Jagannadha) Syst Biol Reprod Med 2016-09-13

...BRCA1 and H2AX. In the present study, a two-dimensional electrophoresis (2DE) proteomic approach was employed to identif...

In vitro and in vivo correlates of physiological and neoplastic human Fallopi...

Yamamoto(Yusuke),Ning(Gang),Howitt(Brooke ... J Pathol 2016-08-10

...BRCA1 or BRCA2 mutations have documented a pre-metastatic intramucosal neoplasm that is found almost exclusively in the ...

miRNA expression patterns in normal breast tissue and invasive breast cancers...

Vos(Shoko),Vesuna(Farhad),Raman(Venu),van ... Oncotarget 2016-08-18

...BRCA1 and BRCA2 mutation carriers. miRNA profiles of 17 BRCA1- and 9 BRCA2-associated breast carcinomas were analyzed us...

The Angelina effect revisited: Exploring a media-related impact on public awa...

Lebo(Patricia Beatrice),Quehenberger(Franz... Cancer 2016-02-23

...BRCA1 positivity generated considerable media attention. To the authors' knowledge, the current study is the first prosp...

Large-scale genomic analyses link reproductive aging to hypothalamic signalin...

Day(Felix R),Ruth(Katherine S),Thompson(De... Nat Genet 2016-03-07

...BRCA1 associated with any complex trait. Mendelian randomization analyses supported a causal effect of later ANM on brea...

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