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ATM-dependent Phosphorylation of the Fanconi Anemia Protein PALB2 Promotes th...

Guo(Yingying),Feng(Wanjuan),Sy(Shirley M H... J Biol Chem 2016-03-07

...BRCA1, highlighting important roles of the BRCA1-PALB2 interaction in orchestrating cellular responses to genotoxic stre...

A BRCA1-interacting lncRNA regulates homologous recombination.

Sharma(Vivek),Khurana(Simran),Kubben(Nard)... EMBO Rep 2016-08-16

...BRCA1 and RAP80 at DSB sites. In line with a role in regulating HR, DDSR1 interacts with BRCA1 and hnRNPUL1, an RNA-bind...

Assessment of DNA methylation profiling and copy number variation as indicati...

Huang(Katie T),Mikeska(Thomas),Li(Jason),T... BMC Cancer 2016-06-27

...BRCA1, CDH1, CDKN2A, TP73, and GSTP1) in 29 tumour pairs (16 ipsilateral and 13 contralateral). Using the methylation pr...

Computational analysis of the mutations in BAP1, PBRM1 and SETD2 genes reveal...

Piva(Francesco),Giulietti(Matteo),Occhipin... Oncotarget 2016-08-08

...BRCA1-associated protein-1 (BAP1), Polybromo-1 (PBRM1) and Set domain-containing 2 (SETD2). More than 350, 700 and 500 m...

Identification of germline genetic mutations in patients with pancreatic cancer.

Salo-Mullen(Erin E),O'Reilly(Eileen M),Kel... Cancer 2016-04-04

...BRCA1 (4 mutations), p16 (2 mutations), PALB2 (1 mutation), and Lynch syndrome (4 mutations). BRCA1/BRCA2 prevalence was...

Targeting tumor suppressor genes for cancer therapy.

Liu(Yunhua),Hu(Xiaoxiao),Han(Cecil),Wang(L... Bioessays 2016-11-02

...BRCA1/2. Here, we review and summarize the recent findings in cancer genomics, drug development, and molecular cancer bi...

The History of Patenting Genetic Material.

Sherkow(Jacob S),Greely(Henry T) Annu Rev Genet 2016-09-19

...BRCA1 and BRCA2, two genes critical to assessing early-onset breast and ovarian cancer risk, and with a particularly con...

Predicting functional regulatory SNPs in the human antimicrobial peptide gene...

Flores Saiffe Farías(Adolfo),Jaime Herrera... Comput Biol Chem 2016-09-19

...BRCA1, CEBPB, CREB1, EBF1 and ZNF354C for HIV/AIDS; and RUNX2, HIF1A, JUN/AP-1, NR4A2, EGR1 for both diseases). Validati...

Delivering on the promise: poly ADP ribose polymerase inhibition as targeted ...

OʼSullivan Coyne(Geraldine),Chen(Alice),Ku... Curr Opin Oncol 2016-07-08

...BRCA1/2 mutation represents a significant therapeutic advance for patients with this difficult to treat disease. Though ...

MSH2 role in BRCA1-driven tumorigenesis: A preliminary study in yeast and in ...

Maresca(Luisa),Spugnesi(Laura),Lodovichi(S... Eur J Med Genet 2016-08-19

...BRCA1 and MSH2, we studied the effect of the deletion of MSH2 gene on BRCA1-induced genome instability in yeast. Prelimi...

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