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TP53 BRCA1 CRISPR single-cell cancer

Loke(Johnny),Pearlman(Alexander),Upadhyay(... Hum Mol Genet 2016-02-16

...BRCA1 decreased nuclear localization of BRCA1 in response to individual or combination drug treatment. Mutations in BRCA...

Valenti(Fabio),Ganci(Federica),Fontemaggi(... Oncotarget 2016-03-03

...BRCA1 and RAD17 promoters leads to the inhibition of their expression. BRCA1 and RAD17 mRNA expression is reduced in HNS...

White(E Railey),Sun(Luxin),Ma(Zhong),Beckt... ACS Chem Biol 2016-02-22

...BRCA1) with an affinity comparable to phosphorylated peptides. A crystal structure of the peptide bound reveals that the...

Caiata-Zufferey(Maria),Pagani(Olivia),Cina... Genet Med 2016-06-14

Women carrying BRCA1/BRCA2 germ-line mutations have an increased risk of developing breast/ovarian cancer. To minimize t...

Maxwell(Kara N),Wubbenhorst(Bradley),D'And... Genet Med 2016-06-01

...BRCA1/2-negative patients with early-onset breast cancer (diagnosed at younger than 40 years of age).,Thirty-one patient...

Lo Iacono(Marco),Monica(Valentina),Righi(L... J Thorac Oncol 2016-03-08

...BRCA1-associated protein-1 (BAP-1) and neurofibromatosis-2 (NF2), frequently altered in MPM. DNA was obtained from tissu...

Gumaste(P V),Penn(L A),Cymerman(R M),Kirch... Br J Dermatol 2016-03-07

...BRCA1/2 mutation carriers. No studies have shown a statistically significant risk of melanoma in BRCA1 families. BRCA2 m...

Engin(H Billur),Hofree(Matan),Carter(Hanna... Pac Symp Biocomput 2016-04-22

...BRCA1, CBL and HRAS. Our analysis suggests that accounting for mutation-specific perturbations to cancer pathways will b...

Tsou(Shang-Hsun),Chen(Tzer-Ming),Hsiao(Hui... PLoS One 2016-01-13

...BRCA1/2 and wild type p53, apoptosis-related gene Bcl-2 and epithelial-mesenchymal transition (EMT) epithelial marker ge...

Leyton(Yessica),Gonzalez-Hormazabal(Patric... BMC Cancer 2016-01-01

...BRCA1/2-negatives familial BC cases were included for the PALB2 mutation analysis. We use conformational sensitive gel e...

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