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SEOM clinical guidelines in Hereditary Breast and ovarian cancer.

Llort(G),Chirivella(I),Morales(R),Serrano(... Clin Transl Oncol 2016-10-05

...BRCA1 and BRCA2 mutation carriers. Bilateral salpingo-oophorectomy should be offered to women with a BRCA1 or BRCA2 muta...

UK BRCA mutation testing in patients with ovarian cancer.

George(Angela) Br J Cancer 2016-04-05

...BRCA1 and BRCA2, whereby mutations may allow more patients to benefit from targeted agents, including poly(ADP-ribose) p...

DCIS in BRCA1 and BRCA2 mutation carriers: prevalence, phenotype, and express...

Yang(Rachel L),Mick(Rosemarie),Lee(Kathree... J Transl Med 2016-06-16

...BRCA1-associated DCIS did not express ER, PR or HER2, while most BRCA2-associated DCIS did express ER and PR. BRCA1- as ...

Does the age of breast cancer diagnosis in first-degree relatives impact on t...

Semple(John),Metcalfe(Kelly A),Lubinski(Ja... Breast Cancer Res Treat 2016-08-08

...BRCA1 mutations and was 1.6 % for women with BRCA2 mutations. The age of breast cancer diagnosis in the first-degree rel...

Adjuvant radiotherapy for primary breast cancer in BRCA1 and BRCA2 mutation c...

Drooger(Jan),Akdeniz(Delal),Pignol(Jean-Ph... Breast Cancer Res Treat 2016-08-08

...BRCA1 or BRCA2 (BRCA1/2) mutation carriers, with special attention to patients irradiated at age younger than 40 years. ...

Risk prediction model for epithelial ovarian cancer using molecular markers a...

Zhang(Meiying),Zhuang(Guanglei),Sun(Xiangj... J Ovarian Res 2016-08-02

...BRCA1), murine sarcoma viral oncogene homolog B (BRAF) and Kirsten rat sarcoma viral oncogene homolog (KRAS).,Our synthe...

Genetic risk assessment and prevention: the role of genetic testing panels in...

Lerner-Ellis(Jordan),Khalouei(Sam),Sopik(V... Expert Rev Anticancer Ther 2016-06-01

...BRCA1 (5.3%) and BRCA2 (3.6%) and was lowest in PTEN (0.1%), CDH1 (0.1%) and STK11 (0.01%). After BRCA1/2, the prevalenc...

Uninterrupted Sedentary Behavior Downregulates BRCA1 Gene Expression.

Pettapiece-Phillips(Rachael),Kotlyar(Max),... Cancer Prev Res (Phila) 2016-10-18

...BRCA1 levels may mitigate the effect of the mutation. Whether physical activity modulates BRCA1 expression and whether l...

Association between XRCC3 Thr241Met Polymorphism and Risk of Breast Cancer: M...

Chai(Fan),Liang(Yan),Chen(Li),Zhang(Fan),J... Med Sci Monit 2016-06-21

...BRCA1/2 mutations, ionized radiation, and chemical carcinogens, are related with breast cancer. X-ray repair cross-compl...

Constitutional de novo deletion of the FBXW7 gene in a patient with focal seg...

Roversi(Gaia),Picinelli(Chiara),Bestetti(I... Sci Rep 2016-08-24

...BRCA1, BRCA2, TP53, PALB2 and WT1 genes were excluded by performing sequencing and MLPA analysis; similarly, we ruled ou...

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