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The repertoire of somatic genetic alterations of acinic cell carcinomas of th...

Guerini-Rocco(Elena),Hodi(Zsolt),Piscuogli... J Pathol 2016-06-06

...BRCA1, ERBB4, ERBB3, INPP4B, and FGFR2. Copy number alteration analysis revealed complex patterns of gains and losses si...

Genomic hallmarks of homologous recombination deficiency in invasive breast c...

Manié(Elodie),Popova(Tatiana),Battistella(... Int J Cancer 2016-05-31

...BRCA1/2 and other genes was also investigated. In the in-house dataset, HRD was predicted in 5% (20/385) of sporadic tum...

Identification of novel PARP-1 inhibitors: Drug design, synthesis and biologi...

Xie(Zhouling),Zhou(Youli),Zhao(Wei),Jiao(H... Bioorg Med Chem Lett 2016-05-31

...BRCA1-deficient MDA-MB-436 cells. Our results demonstrated that of all AG014699 derivatives synthesized in this work, co...

Cancer predisposing BARD1 mutations affect exon skipping and are associated w...

Ratajska(Magdalena),Matusiak(Magdalena),Ku... Oncol Rep 2016-08-08

...BRCA1 and is required for its stability and tumor-suppressor functions. In breast cancer and other epithelial cell carci...

Effects of aluminium chloride and aluminium chlorohydrate on DNA repair in MC...

Farasani(A),Darbre(P D) J Inorg Biochem 2016-10-11

...BRCA1 mRNA as determined by real-time RT-PCR and BRCA1 protein as determined by Western immunoblotting. Reduced levels o...

The role of germline mutations in the BRCA1/2 and mismatch repair genes in me...

Maia(Sofia),Cardoso(Marta),Paulo(Paula),Pi... Fam Cancer 2016-10-05

...BRCA1/2 and/or MLH1, MSH2 and MSH6. Two patients were found to harbor the same MSH2 mutation and a third patient carried...

Mutation of the BRCA1 SQ-cluster results in aberrant mitosis, reduced homolog...

Beckta(Jason M),Dever(Seth M),Gnawali(Nish... Oncotarget 2016-08-16

...BRCA1) gene are catalysts for breast and ovarian cancers. Most mutations are associated with the BRCA1 N- and C-terminal...

Aluminum-Dependent Terminal Differentiation of the Arabidopsis Root Tip Is Me...

Sjogren(Caroline A),Bolaris(Stephen C),Lar... Plant Cell 2016-07-25

...BRCA1 and PARP2, with gel-shift analysis showing that SOG1 can physically associate with the BRCA1 promoter in vitro. Al...

A novel BRCA2 in frame deletion in a Tunisian woman with early onset sporadic...

Hadiji-Abbes(N),Trifa(F),Choura(M),Khabir(... Pathol Biol (Paris) 2016-07-01

...BRCA1/2 genes are associated with a high risk for breast cancer development. However, the true contribution of BRCA1/2 m...

Living With Genetic Vulnerability: a Life Course Perspective.

Hamilton(Rebekah J),Innella(Nancy A),Bound... J Genet Couns 2016-09-29

...BRCA1 or BRCA2 gene mutation long after the initial diagnosis. These women's experiences across time reflect the concept...

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