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53BP1 and the LINC Complex Promote Microtubule-Dependent DSB Mobility and DNA...

Lottersberger(Francisca),Karssemeijer(Roos... Cell 2016-02-25

...BRCA1-deficient cells showing that DSB mobility can be detrimental in cells with numerous DSBs. In contrast, under physi...

Exploring DNA methylation changes in promoter, intragenic, and intergenic reg...

Rauscher(Garth H),Kresovich(Jacob K),Pouli... BMC Cancer 2016-07-12

...BRCA1, CD44, ESR1, GSTM2, GSTP1, MAGEA1, MSI1, NFE2L3, RASSF1A, RUNX3, SIX3 and TFF1), far-upstream regions (EN1, PAX3, ...

Suppression of Homologous Recombination by insulin-like growth factor-1 inhib...

Amin(Oreekha),Beauchamp(Marie-Claude),Nade... BMC Cancer 2016-07-12

Impairment of homologous recombination (HR) is found in close to 50 % of ovarian and breast cancer. Tumors with BRCA1 mu...

Dose-response effects of aerobic exercise on estrogen among women at high ris...

Schmitz(Kathryn H),Williams(Nancy I),Konto... Breast Cancer Res Treat 2016-09-09

...BRCA1/2 mutation, family history) focus on reducing estrogen exposure. Women at elevated risk may be interested in less ...

Association between the BsmI Polymorphism in the Vitamin D Receptor Gene and ...

Rashid(Muhammad Usman),Muzaffar(Merium),Kh... PLoS One 2016-06-15

...BRCA1/2 status and in 1,012 controls from Pakistan. The association between SNP genotypes and breast cancer risk was inv...

Functional Link between BRCA1 and BAP1 through Histone H2A, Heterochromatin a...

Fukuda(Takayo),Tsuruga(Tomoko),Kuroda(Taka... Curr Cancer Drug Targets 2016-10-19

...BRCA1 interacts with BARD1 to constitute a RING heterodimer-type E3 ubiquitin ligase. BRCA1-associated protein 1 (BAP1) ...

Genomic profiling of CHEK2*1100delC-mutated breast carcinomas.

Massink(Maarten P G),Kooi(Irsan E),Martens... BMC Cancer 2016-06-29

...BRCA1 mutated breast cancers.,We performed high-resolution SNP array and gene expression profiling of 120 familial breas...

Ten-year survival after epithelial ovarian cancer is not associated with BRCA...

Kotsopoulos(Joanne),Rosen(Barry),Fan(Isabe... Gynecol Oncol 2016-04-28

...BRCA1 mutations and 68 (4.8%) had BRCA2 mutations. A status of no residual disease was achieved by 39% of non-carriers a...

The Hsp90 inhibitor SNX-7081 is synergistic with fludarabine nucleoside via D...

Kaufman(Kimberley L),Jenkins(Yiping),Aloma... Oncotarget 2016-09-28

...BRCA1 and cyclin D1, and cell death is triggered following reductions of MYC and nucleolin and an accumulation of apopto...

Addressing health disparities in Hispanic breast cancer: accurate and inexpen...

Dean(Michael),Boland(Joseph),Yeager(Meredi... Gigascience 2016-07-25

Germline mutations in the BRCA1 and BRCA2 genes account for 20-25 % of inherited breast cancers and about 10 % of all br...

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