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TP53 BRCA1 CRISPR single-cell cancer

Estrada-Bernal(Adriana),Chatterjee(Moumita... Cell Cycle 2016-10-13

...BRCA1, and RAD51), and by functional GFP-reporter assays for homologous recombination (HR) and non-homologous end-joinin...

Gill(Sonja J),Travers(Jon),Pshenichnaya(Ir... PLoS One 2016-06-10

...BRCA1/2 mutations, which confer deficiency in DNA double-strand break (DSB) repair by homologous recombination (HR). Thi...

Alexandrov(Ludmil B),Nik-Zainal(Serena),Si... Nat Commun 2016-05-17

Targeting defects in the DNA repair machinery of neoplastic cells, for example, those due to inactivating BRCA1 and/or B...

Weber(Julia),Öllinger(Rupert),Friedrich(Ma... Proc Natl Acad Sci U S A 2016-02-29

...Brca1/2 alterations, explaining mutational spectra in human ICC/HCC. Our studies show that multiplexed CRISPR/Cas9 can b...

Pennisi(Rosa),Ascenzi(Paolo),di Masi(Aless... Biomolecules 2016-07-13

...BRCA1, BRCA2, CHK1, DNA-PKcs, FANCA, and the MRE11/RAD50/NBN complex, have been described to be client proteins of Hsp90...

Dizdar(Omer),Arslan(Cagatay),Altundag(Kadr... Expert Opin Pharmacother 2016-06-27

...BRCA1 and POLQ recruitment to sites of DNA repair. Breast cancer subgroups with germline BRCA mutations or non-mutationa...

Weiderpass(Elisabete),Tyczynski(Jerzy E) Mol Diagn Ther 2016-09-05

...BRCA1 or BRCA2 gene (BRCAm) have a significantly increased risk of developing ovarian cancer. Epidemiology data in large...

Sénéchal(C),Rousset-Jablonski(C) Gynecol Obstet Fertil 2016-08-03

...BRCA1/2 women: absence of oncological risk due to stimulation in BRCA1/2 women not clearly demonstrated, oocyte vitrific...

Mundy(Sheraden A),Krock(Bryan L),Mao(Rong)... Am J Med Genet A 2016-11-04

...BRCA1-associated protein required for ATM activation-1 (BRAT1) gene. Variants in BRAT1 have been identified to cause let...

Liu(Ying),Pike(Malcolm C),Wu(Nancy),Lin(Yv... PLoS One 2016-06-07

...Brca1 to follow up on our earlier observation that absence of a functional Brca1 in these important regulators of menstr...

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