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TP53 BRCA1 CRISPR single-cell cancer

Kondrashova(Olga),Love(Clare J),Lunke(Seba... PLoS One 2016-06-20

...BRCA1, BRCA2, ERBB2 and CCNE1 copy number changes in DNA extracted from snap-frozen and FFPE tumour tissue, with 100% se...

Suberbielle(Elsa),Djukic(Biljana),Evans(Ma... Nat Commun 2016-06-29

...BRCA1 levels in primary neuronal cultures. In wild-type mice, knocking down neuronal BRCA1 in the dentate gyrus caused i...

Scalia-Wilbur(Jennifer),Colins(Bradley L),... Semin Radiat Oncol 2016-09-19

...BRCA1 and BRCA2 are available. However, the indications for both screening and prevention of inherited predispositions b...

Meeks(Huong D),Song(Honglin),Michailidou(K... J Natl Cancer Inst 2016-03-14

...BRCA1 variant carriers. All statistical tests were two-sided.,The K3326X variant was associated with breast (ORw = 1.28,...

Vasanthakumar(Aparna),Arnovitz(Stephen),Ma... Blood 2016-06-06

...BRCA1 deficiency on bone marrow (BM) function are unknown. To test the hypothesis that Brca1 is essential in hematopoies...

Kelkar(Pranav),Walter(Anna),Papadopoulos(S... Nucleus 2016-11-01

...BRCA1 localization in the ovarian cancer cell lines SKOV-3 and Caov-3, Nesprin-2 and BRCA1 were localized to the NE enve...

Wang(Bing),Chu(Daniel),Feng(Ying),Shen(Yuq... J Med Chem 2016-05-18

...BRCA1/2, with EC50 = 0.3 nM (MX-1) and 5 nM (Capan-1), respectively. (8S,9R)-47 is orally available, displaying favorabl...

Orthwein(Alexandre),Noordermeer(Sylvie M),... Nature 2016-01-15

...BRCA1 with PALB2-BRCA2 to constrain BRCA2 function to the S/G2 phases in human cells. We found that the BRCA1-interactio...

Hussein(Yaser R),Ducie(Jennifer A),Arnold(... Am J Surg Pathol 2016-06-29

...BRCA1 or BRCA2 germline mutation retrieved from our institutional files, 23 patients had a germline mutation of BRCA1 an...

Mace(Thomas A),Shakya(Reena),Elnaggar(Omar... Oncotarget 2016-10-31

...Brca1 alleles (KPC-Brca1 mice). Mice with confirmed tumor burden were treated orally with vehicle or 30 mg/kg BMS-911543...

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