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Structural and Mechanistic Analysis of the Slx1-Slx4 Endonuclease.

Gaur(Vineet),Wyatt(Haley D M),Komorowska(Wer… Cell Rep 0000-00-00

...SLX4. At the present time, little is known about the structure of SLX1-SLX4 or its mechanism of action. Here, we report ...

Structure and mechanism of nucleases regulated by SLX4.

Nowotny(Marcin),Gaur(Vineet) Curr Opin Struct Biol 0000-00-00

SLX4 is a multidomain platform that regulates various proteins that are involved in genome maintenance and stability. Am...

Crystal structure and SUMO binding of Slx1-Slx4 complex.

Lian(Fu-Ming),Xie(Si),Qian(Chengmin) Sci Rep 0000-00-00

The SLX1-SLX4 complex is a structure-specific endonuclease that cleaves branched DNA structures and plays significant ro...

HIV-1 Vpr degrades the HLTF DNA translocase in T cells and macrophages.

Lahouassa(Hichem),Blondot(Marie-Lise),Chauve… Proc Natl Acad Sci U S A 0000-00-00

...SLX4) complex and to promote cell cycle arrest. Vpr also interferes with the base-excision repair pathway by antagonizin...

Dimerization of SLX4 contributes to functioning of the SLX4-nuclease complex.

Yin(Jinhu),Wan(Bingbing),Sarkar(Jaya),Horvat… Nucleic Acids Res 0000-00-00

...SLX4 acts as a scaffold for building this complex, the molecular basis underlying this function of SLX4 remains unclear....

Paternal or Maternal Uniparental Disomy of Chromosome 16 Resulting in Homozygos…

Donovan(Frank X),Kimble(Danielle C),Kim(Yong… Hum Mutat 0000-00-00

...SLX4 genes, both located on chromosome 16, were the affected recessive FA genes in three and one family respectively. Ge...

Slx4 scaffolding in homologous recombination and checkpoint control: lessons fr…

Cussiol(José R),Dibitetto(Diego),Pellicioli(… Chromosoma 0000-00-00

...Slx4 protein plays key roles in the processing of recombination intermediates, functioning as a scaffold to coordinate t...

Budding Yeast SLX4 Contributes to the Appropriate Distribution of Crossovers an…

Higashide(Mika),Shinohara(Miki) G3 (Bethesda) 0000-00-00

...Slx4 has been believed to play only a minor role in meiotic recombination. Here, we report that Slx4 is involved in prop...

A high rate of telomeric sister chromatid exchange occurs in chronic lymphocyti…

Medves(Sandrine),Auchter(Morgan),Chambeau(La… Br J Haematol 0000-00-00

...SLX4, MUS81 and GEN1, involved in the resolution of HJ. Altogether, our results suggest that the telomere maintenance me...

Upregulated LINE-1 Activity in the Fanconi Anemia Cancer Susceptibility Syndrom…

Brégnard(Christelle),Guerra(Jessica),Déjardi… EBioMedicine 0000-00-00

...SLX4(FANCP) deficiency as a working model, we questioned the trigger for chronic inflammation in FA. We found that absen...

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