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The effect of personal medical history and family history of cancer on the up...

van der Aa(Jessica E),Hoogendam(Jacob P),B... Fam Cancer 2016-08-26

...BRCA1 mutation carrier, 28.0% BRCA2 mutation carrier, 27.0% with familial susceptibility) with 87.2% RRSO uptake. The me...

DNA repair prognostic index modelling reveals an essential role for base exci...

Abdel-Fatah(Tarek M A),Arora(Arvind),Mosel... Oncotarget 2016-08-03

...BRCA1, ATR, ATM, DNA-PKcs, Chk1, Chk2, p53, and TOPO2. Multivariate Cox proportional hazards models (with backward stepw...

Clinical Actionability of Multigene Panel Testing for Hereditary Breast and O...

Desmond(Andrea),Kurian(Allison W),Gabree(M... JAMA Oncol 2016-03-29

...BRCA1/2 alone, whether finding such mutations will alter clinical management is unknown.,To define the potential clinica...

In silico analysis of SIGMAR1 variant (rs4879809) segregating in a consanguin...

Ullah(Muhammad Ikram),Ahmad(Arsalan),Raza(... Neurogenetics 2016-06-13

...BRCA1 binding sites with significant scores due to this variation. Our results indicate that the 3'-UTR SIGMAR1 variant ...

Expression of proteins involved in DNA damage response in familial and sporad...

Partipilo(Giulia),Simone(Giovanni),Scatton... Int J Cancer 2016-02-09

...BRCA1 (nBRCA1) expression was associated with positive PgR (p = 0.037). Negative association was found between nBRCA1 ex...

Outcome of neoadjuvant chemotherapy in BRCA1/2 mutation positive women with a...

Mahdi(Haider),Gockley(Allison),Esselen(Kat... Gynecol Oncol 2016-04-12

To investigate whether patients with germline BRCA1/2 mutations who received neoadjuvant chemotherapy (NAC) for advanced...

Targeted Resequencing of 30 Genes Improves the Detection of Deleterious Mutat...

Rajkumar(Thangarajan),Meenakumari(Balaiah)... Asian Pac J Cancer Prev 2016-05-05

...BRCA1 and BRCA2, we now had 45 mutations in 44 patients. BRCA1c.68_69delAG;p.Glu23ValfsX16 mutation was the most common,...

Association of HO-1 and BRCA1 Is Critical for the Maintenance of Cellular Hom...

Labanca(Estefanía),De Luca(Paola),Gueron(G... Mol Cancer Res 2016-05-16

...BRCA1 protein to activate HO-1 promoter activity. In summary, these results show that the activation of BRCA1-NRF2/HO-1 ...

Brca1 is expressed in human microglia and is dysregulated in human and animal...

Noristani(Harun Najib),Sabourin(Jean Charl... Mol Neurodegener 2016-03-21

...Brca1 in ALS. Finally, we established that Brca1 protein is specifically expressed in human spinal microglia and is up-r...

Using a Historical Lens to Envision the Next Generation of Genomic Translatio...

McBride(Colleen M),Abrams(Leah R),Koehly(L... Public Health Genomics 2016-06-01

...BRCA1, and the emergence of direct-to- consumer genetic testing - to illustrate how these scientific meta-narratives hav...

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