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TP53 BRCA1 CRISPR single-cell cancer

Tan(Adeline),Cohen(Paul),Raoofi(Mooska),Ta... Acta Cytol 2016-07-06

...BRCA1-associated protein 1 (BAP1) dysfunction compatible with diffuse malignant peritoneal mesothelioma (DMPM).,We descr...

Jiang(Lei),Wu(Xiaohua),He(Fang),Liu(Ying),... PLoS One 2016-07-11

...Brca1-/-, Ubc13-/- and translesion-DNA-synthesis deficient cells including Rad18-/- and Rev3-/- were hypersensitive to e...

Ertych(Norman),Stolz(Ailine),Valerius(Oliv... Proc Natl Acad Sci U S A 2016-07-22

...BRCA1 in mitosis. Aurora-A, in turn, then phosphorylates BRCA1 itself, thereby inhibiting the mitotic function of BRCA1 ...

Shariati-Kohbanani(M),Zare-Bidaki(M),Tagha... Cell Mol Biol (Noisy-le-grand) 2016-10-26

...BRCA1) or its down-regulation are involved in its development. Down-regulation of BRCA1 expression by hypermethylation o...

Alkema(Nicolette G),Wisman(G Bea A),van de... Drug Resist Updat 2016-10-17

...BRCA1/2-mutation carriers that could potentially benefit from the synthetic lethality of PARP inhibitors. This integrate...

Tkáč(Ján),Xu(Guotai),Adhikary(Hemanta),You... Mol Cell 2016-06-29

...BRCA1-deficient tumor cells. We conclude that mammalian DNA end resection triggers its own inhibition via the recruitmen...

Choi(Young Eun),Meghani(Khyati),Brault(Mar... Cell Rep 2016-10-20

High-grade serous ovarian carcinomas (HGSOCs) with BRCA1/2 mutations exhibit improved outcome and sensitivity to double-...

Bittremieux(Mart),Parys(Jan B),Pinton(Paol... Biochim Biophys Acta 2016-07-19

...BRCA1, and Beclin 1, as direct and critical regulators of Ca(2+)-transport systems located at the ER membranes, includin...

Eccles(Diana M),Balmaña(Judith),Clune(Joe)... Adv Ther 2016-09-29

One of the most significant risk factors for the development of ovarian cancer (OC) is a genetic mutation in BRCA1 (brea...

Galateau-Salle(Francoise),Churg(Andrew),Ro... J Thorac Oncol 2016-10-21

...BRCA1-associated protein 1 gene in sporadic and hereditary mesothelioma has opened up a variety of novel molecular, clin...

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