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Uninterrupted Sedentary Behavior Downregulates BRCA1 Gene Expression.

Pettapiece-Phillips(Rachael),Kotlyar(Max),... Cancer Prev Res (Phila) 2016-10-18

...BRCA1 levels may mitigate the effect of the mutation. Whether physical activity modulates BRCA1 expression and whether l...

Clinical Practice Guideline for the prevention and early detection of breast ...

Singer(C F),Tea(M K),Pristauz(G),Hubalek(M... Wien Klin Wochenschr 2016-09-19

...BRCA1 or 2 mutations. It replaces the previous version of the "Clinical Practice Guideline for the Prevention and Early ...

Transcriptome sequencing of human breast cancer reveals aberrant intronic tra...

Forootan(Shiva Seyed),Butler(Joe M),Garden... Int J Oncol 2016-09-23

...BRCA1/2 and NF1 did not show intronic overexpression or truncated splice variants in cancers. These findings emphasize t...

Targeted DNA Sequencing Detects Mutations Related to Susceptibility among Fam...

Yu(Yang),Dong(Li),Li(Dapeng),Chuai(Shaokun... Sci Rep 2016-09-28

...BRCA1 SS955S, BRCA2 G2508S, and a GNAS inframe insertion. We demonstrated a novel approach to help diagnose and elucidat...

Targeted massively parallel sequencing of a panel of putative breast cancer s...

Li(Jun),Meeks(Huong),Feng(Bing-Jian),Heale... J Med Genet 2016-10-12

...BRCA1/2 women with familial breast cancer. Putative deleterious mutations were genotyped in relevant family members to a...

BRCA1/2 mutations associated with progression-free survival in ovarian cancer...

Harter(Philipp),Johnson(Toby),Berton-Rigau... Gynecol Oncol 2016-06-28

...BRCA1/2 mutations (BRCA1/2 carriers: pazopanib 14%, placebo 16%). Median PFS was longer in BRCA1/2 mutation carriers tha...

Poor response to platinum-based chemotherapy is associated with KRAS mutation...

Zhou(Hongxuan),Dai(Yun),Zhu(Liqun),Wang(Ch... J Int Med Res 2016-11-14

...BRCA1 was positively correlated with survival duration.,KRAS mutation status and BRCA1 tumour expression are potential b...

Genetic characterization of early onset ovarian carcinoma.

Bernards(Sarah S),Norquist(Barbara M),Harr... Gynecol Oncol 2016-06-01

...BRCA1, BRCA2, BRIP1, MLH1, MSH2, MSH6, PALB2, PMS2, RAD51D, and RAD51C) and additional candidate genes in DNA repair (AT...

Molecular Basis for Phosphorylation-dependent SUMO Recognition by the DNA Rep...

Anamika,Spyracopoulos(Leo) J Biol Chem 2016-08-01

...BRCA1 A complex, and plays a key role in the recruitment process through the binding of Lys(63)-linked poly-Ub chains by...

Low concentrations of 5-aza-2'-deoxycytidine induce breast cancer stem cell d...

Phan(Nhan Lu-Chinh),Trinh(Ngu Van),Pham(Ph... Onco Targets Ther 2016-01-05

...BRCA1, BRCA2, p15, p16, p53, and PTEN, and antitumor drug resistance.,DAC treatment caused significant BCSC differentiat...

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