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TP53 BRCA1 CRISPR single-cell cancer

Aloraifi(Fatima),Boland(Michael R),Green(A... Surg Oncol 2016-02-22

...BRCA1 or BRCA2 genes have up to an 85% risk of developing breast cancer in their lifetimes. These patients are candidate...

Farzin(Mahtab),Toon(Christopher W),Clarkso... Pathology 2016-04-22

BRCA1-associated protein 1 (BAP1) is a tumour suppressor gene frequently inactivated in mesothelioma, rarely also in ass...

Cabanski(Maciej),Fields(Brett),Boue(Stepha... Inflamm Res 2016-03-07

...BRCA1, and STAT1.,These systems biology-derived candidate mechanisms common to susceptible mouse models may enhance unde...

Upton(Dannielle H),Fuller(Emily S),Colvin(... Horm Cancer 2016-03-16

...Brca1 disruption, denoted Brca1(GC-/-). Furthermore, ovary-specific Brca1(GC-/-) was combined with global Trp53 haploins...

Li(Dongguo),Xia(Hong),Li(Zhen-ya),Hua(Lin)... Biomed Res Int 2016-02-04

...BRCA1-miR-143-miR-145 pairs was selected for experimental validation. The study results indicated that BRCA1 positively ...

Price(R Jordan),Lillycrop(Karen A),Burdge(... Nutr Res 2016-03-01

...BRCA1 and BRCA2. FA treatment induced dose-related increases in BRCA1 mRNA expression in HepG2, Huh-7D12, Hs578T, and JU...

Holter(Spring),Borgida(Ayelet),Dodd(Anna),... J Clin Oncol 2016-01-08

The main purpose of this study was to determine the prevalence of pathogenic BRCA1 and BRCA2 mutations in a consecutivel...

Palomba(Grazia),Loi(Angela),Porcu(Eleonora... BMC Cancer 2016-02-05

...BRCA1/2-mutation-negative breast cancer to 2171 healthy Sardinian blood donors. DNA was genotyped using GeneChip Human M...

Scanlon(Susan E),Glazer(Peter M) DNA Repair (Amst) 2016-04-28

...BRCA1 and MLH1, revealing a mechanism by which tumor suppressor genes can be inactivated. The discoveries of the hypoxic...

Alli(Elizabeth),Ford(James M) DNA Repair (Amst) 2016-04-28

Since its discovery, the BRCA1 tumor suppressor has been shown to play a role in multiple DNA damage response pathways. ...

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