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Biochemical mechanism of DSB end resection and its regulation.

Daley(James M),Niu(Hengyao),Miller(Adam S)... DNA Repair (Amst) 2016-04-28

...BRCA1 and 53BP1 in regulating resection initiation in mammalian cells, the influence of chromatin in the resection proce...

Increased DNA damage and repair deficiency in granulosa cells are associated ...

Zhang(Dongdong),Zhang(Xiaoqian),Zeng(Ming)... J Assist Reprod Genet 2016-06-27

...BRCA1 immunofluorescence.,DSBs in granulosa cells increase and DSB repair ability, characterized by BRCA1 foci, decrease...

Differential Potential of Pharmacological PARP Inhibitors for Inhibiting Cell...

Węsierska-Gądek(Józefa),Mauritz(Matthias),... J Cell Biochem 2016-08-09

...BRCA1-positive BT-20 cells, but not BRCA1-deficient SKBr-3 cells. These results raised the possibility that other PARP-1...

Second primary breast cancer in BRCA1 and BRCA2 mutation carriers: 10-year cu...

Menes(Tehillah S),Terry(Mary Beth),Goldgar... Breast Cancer Res Treat 2016-02-24

BReast CAncer genes 1 and 2 (BRCA1 and BRCA2) mutation carriers diagnosed with breast cancer are at increased risk of de...

The PARP inhibitor AZD2281 (Olaparib) induces autophagy/mitophagy in BRCA1 an...

Arun(Banu),Akar(Ugur),Gutierrez-Barrera(An... Int J Oncol 2016-03-21

...BRCA1 or BRCA2 mutations and 9 different BRCA wild-type cell lines with BRCA1 allelic loss. We found that AZD2281 was th...

Annotation of Sequence Variants in Cancer Samples: Processes and Pitfalls for...

Lee(Lobin A),Arvai(Kevin J),Jones(Dan) J Mol Diagn 2016-03-15

...BRCA1 and TP53. We compare and contrast the general principles and lines of evidence commonly used to distinguish the si...

Does rapid genetic counseling and testing in newly diagnosed breast cancer pa...

Wevers(Marijke R),Ausems(Margreet G E M),V... Genet Med 2016-10-20

Female breast cancer patients carrying a BRCA1/2 mutation have an increased risk of second primary breast cancer. Rapid ...

XomAnnotate: Analysis of Heterogeneous and Complex Exome- A Step towards Tran...

Talukder(Asoke K),Ravishankar(Shashidhar),... PLoS One 2016-01-19

...BRCA1/BRCA2 breast cancer exome data. The results showed that the most significantly affected pathways across all sample...

Mitochondrial fission determines cisplatin sensitivity in tongue squamous cel...

Fan(Song),Liu(Bodu),Sun(Lijuan),Lv(Xiao-bi... Oncotarget 2016-04-18

...BRCA1 transactivated miR-593-5p expression and attenuated cisplatin sensitivity in vitro. The BRCA1-miR-593-5p-MFF axis ...

Loss of the N-terminal methyltransferase NRMT1 increases sensitivity to DNA d...

Bonsignore(Lindsay A),Butler(Jill Sergeske... Oncotarget 2016-04-05

...BRCA1 and BRCA2, its loss may result in tumors with enhanced sensitivity to diverse DNA damaging chemotherapeutics.

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