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When is a mutation not a mutation: the case of the c.594-2A>C splice variant ...

Wong-Brown(Michelle),McPhillips(Mary),Glee... Hered Cancer Clin Pract 2016-02-17

Since the identification of BRCA1 there has only ever been described two bi-allelic mutation carriers, one of whom was s...

MRN, CtIP, and BRCA1 mediate repair of topoisomerase II-DNA adducts.

Aparicio(Tomas),Baer(Richard),Gottesman(Ma... J Cell Biol 2016-08-01

...BRCA1 are required for both the removal of Top2-DNA adducts and the subsequent resection of Top2-adducted DSB ends. More...

Chromosomal microarray provides enhanced targetable gene aberration detection...

Mukherjee(S),Ma(Z),Wheeler(S),Sathanoori(M... Cancer Genet 2016-09-22

...BRCA1 and NF1 among male patients with lung cancer. For clinically actionable targets, 23% had targetable CNVs when no p...

Low prevalence of HER2 positivity amongst BRCA1 and BRCA2 mutation carriers a...

Evans(D G),Lalloo(F),Howell(S),Verhoef(S),... Breast Cancer Res Treat 2016-11-14

The aim of this study is to delineate more clearly the prevalence of HER2+ breast cancer in women with germline BRCA1/2 ...

LncRNA NBR2 engages a metabolic checkpoint by regulating AMPK under energy st...

Liu(Xiaowen),Xiao(Zhen-Dong),Han(Leng),Zha... Nat Cell Biol 2016-08-22

...BRCA1 gene 2) is induced by the LKB1-AMPK pathway under energy stress. On energy stress, NBR2 in turn interacts with AMP...

[Assessment of applicability of archived cytological lung cancer specimens fo...

Mityushkina(N V),Ievleva(A G),Poltoratsky(... Vopr Onkol 2016-04-15

...BRCA1, etc.) may increase the therapeutic index of platinum-based drugs. Usually these markers are evaluated using forma...

Contribution of BRCA1 and BRCA2 Germline Mutations to Early Algerian Breast C...

Henouda(Sarra),Bensalem(Assia),Reggad(Rym)... Dis Markers 2016-10-28

...BRCA1 and BRCA2 genes in patients with early-onset breast cancer have not been clearly identified within the Algerian po...

Gene panel testing for hereditary breast cancer.

Winship(Ingrid),Southey(Melissa C) Med J Aust 2016-07-25

Inherited predisposition to breast cancer is explained only in part by mutations in the BRCA1 and BRCA2 genes. Most fami...

Mechanisms of Nuclear Export in Cancer and Resistance to Chemotherapy.

El-Tanani(Mohamed),Dakir(El-Habib),Raynor(... Cancers (Basel) 2016-03-18

...BRCA1, and ABC, play key roles in preventing the development of a malignant phenotype, but those that function as transc...

Metastasis of Pregnancy-Associated Breast Cancer (Suspected to Be Hereditary ...

Okuda(Tomohiro),Yamamoto(Sakura),Matsuo(Se... Case Rep Obstet Gynecol 2016-03-16

...BRCA1/2, though genetic counseling was provided. In cases of pregnancy-related breast cancer, consideration must be give...

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