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Phosphoproteome Analysis of Invasion and Metastasis-Related Factors in Pancre...

Tan(Xiaodong),Liu(Peng),Huang(Yinpeng),Zho... PLoS One 2016-08-05

...BRCA1) were closely involved in apoptosis and p53 signaling pathways. Moreover, four proteins (AKT1, Chk2, p53 and P70S6...

The genetic prediction of risk for gynecologic cancers.

Randall(Leslie M),Pothuri(Bhavana) Gynecol Oncol 2016-08-16

...BRCA1, BRCA2, and DNA mismatch repair genes: MLH1, MSH2, MSH6, and PMS2 are important causal agents in hereditary breast...

The SMC-5/6 Complex and the HIM-6 (BLM) Helicase Synergistically Promote Meio...

Hong(Ye),Sonneville(Remi),Agostinho(Ana),M... PLoS Genet 2016-08-09

...BRCA1 ortholog BRC-1. Furthermore, the combined deletion of smc-5 and him-6 leads to an irregular distribution of conden...

Genomic Biomarkers for Breast Cancer Risk.

Walsh(Michael F),Nathanson(Katherine L),Co... Adv Exp Med Biol 2016-08-10

...BRCA1 or BRCA2, moderately penetrant mutations of genes such as CHEK2, as well as more common genomic variants, includin...

Frequency and Significance of Abnormal Pancreatic Imaging in Patients with BR...

Chahla(Elie),Cheesman(Antonio),Mahon(Suzan... Scientifica (Cairo) 2016-04-12

...BRCA1 and BRCA2 mutation carriers. Methods. A retrospective review of patient medical records with known BRCA1 and BRCA2...

[(18)F]FluorThanatrace uptake as a marker of PARP1 expression and activity in...

Edmonds(Christine E),Makvandi(Mehran),Lieb... Am J Nucl Med Mol Imaging 2016-04-12

The nuclear enzyme PARP1 plays a central role in sensing DNA damage and facilitating repair. Tumors with BRCA1/2 mutatio...

A unified analytic framework for prioritization of non-coding variants of unc...

Mucaki(Eliseos J),Caminsky(Natasha G),Perr... BMC Med Genomics 2016-09-30

...BRCA1, BRCA2, CDH1, CHEK2, PALB2, and TP53 were synthesized for solution hybridization enrichment. Unique and divergent ...

Effect of lifestyle and reproductive factors on the onset of breast cancer in...

Rieder(Viktoria),Salama(Mohamed),Glöckner(... Mol Genet Genomic Med 2016-04-12

The birth year-dependent onset of breast cancer (BC) in BRCA1/2 mutation carriers suggests a risk-modifying role for rep...

BRCA1 positively regulates FOXO3 expression by restricting FOXO3 gene methyla...

Gong(C),Yao(S),Gomes(A R),Man(E P S),Lee(H... Oncogenesis 2016-04-05

...BRCA1-competent MCF-7, whereas expression of BRCA1 restored FOXO3 expression in BRCA1-defective HCC70 and MDA-MB-468 cel...

MicroRNA-206 is differentially expressed in Brca1-deficient mice and regulate...

Wronski(A),Sandhu(G K),Milevskiy(M J G),Br... Oncogenesis 2016-04-05

Depletion of Brca1 leads to defects in mouse mammary gland development and mammary tumors in humans and mice. To explore...

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