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Exome-Wide Association Analysis Identifies Rare Germline Susceptibility Varia...

Bu(R),Iqbal(K),Parvathareddy(SK),Azam(S),Q... Int J Mol Sci 2026-02-11

...BRCA1/2 explain part of the hereditary risk, the contribution of rare coding variants in Arab EOBC remains unclear. Whol...

Germline genetic profiling utilizing multigene panel testing in Jordanian pat...

Abdel-Razeq(H),Saleh(Y),Hani(HB),Abdel-Raz... BMC Cancer 2026-02-10

...BRCA1, and MSH6. Half (n = 11, 50.0%) of patients with P/LP variants or APC increased risk allele communicated results w...

Concurrent Germline-Somatic Alterations and Associations with Cancer Outcomes...

Pal(LR),Schäffer(AA),Avila(S),Wooten(J),Bu... Res Sq 2026-02-02

...BRCA1/somatic TP53 (n=40 and n=38 studies, respectively). Statistical testing was performed in 41.6% (n=82) of studies t...

Single-Electrode High-Throughput 12-Well Array Electrochemiluminescence Imagi...

Dong(Y),Fu(B),Wu(H),Jie(G) Anal Chem 2026-02-24

...BRCA1 and BRCA2). Two newly explored luminophores, the Eu-luminol complex and Ru/Zn MOF with blue and orange-red high-in...

Prostate cancer germline variants with therapeutic implications.

Bitaraf(M),Castro(E),Sharifi(N) Trends Mol Med 2026-05-00

...BRCA1, BRCA2, and HSD3B1 are the most prevalent alterations in men with advanced prostate cancer and are associated with...

Clinical and biological characteristics associated with loss-of-heterozygosit...

Blanc-Durand(F),Rouleau(E),Pautier(P),Ngoi... J Gynecol Oncol 2026-01-00

...BRCA1 mutations and TERC amplification whereas LOH-low with low-grade endometrioid, MSI, ARID1A, PIK3CA, CTNNB1, and PTE...

Overcoming Resistance to PARP Inhibitors in BRCA-Mutated Cancers: Mechanisms ...

Guo(J),Wang(Y),Li(J),Jiang(Z) J Cancer 2026-00-00

...BRCA1 and BRCA2 are essential for homologous recombination (HR) repair. Mutations in BRCA1/2 compromise HR repair effica...

Clinicopathologic Spectrum and Intraprostatic Heterogeneity of Primary Mismat...

Martin(D),Cheung(CC),Yang(C),Beauchamp(L),... Am J Surg Pathol 2026-09-15

...BRCA1, and BRCA2. Germline testing performed in 15 cases identified Lynch syndrome in 5 (33%). MMR immunohistochemistry ...

Comprehensive Genomic Profiling Reveals the Mutational Spectrum and Clinical ...

Ammous-Boukhris(N),Abdelmaksoud-Dammak(R),... Cancers (Basel) 2026-08-29

...BRCA1/BRCA2 were identified in 19 cases (11.51%), including 8 in BRCA1 and 11 in BRCA2. The presence of BRCA P/LPVs asso...

Genomic Landscape of 6597 Hong Kong HBOC Patients: Implications for Beyond-BR...

Kwong(A),Ho(CYS),Tey(SK),Au(CH),Ma(ESK) Int J Mol Sci 2026-08-24

...BRCA1/2. Here we highlight the clinical value of extending testing to beyond BRCA susceptibility genes for improved prev...

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