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A two-stage approach to genetic risk assessment in primary care.

Biswas(Swati),Atienza(Philamer),Chipman(Jo... Breast Cancer Res Treat 2016-10-14

...BRCA1 and BRCA2 mutation carriers. They require extensive information on the counselee and her family history, and thus ...

Identification of a Small Molecule Inhibitor of RAD52 by Structure-Based Sele...

Sullivan(Katherine),Cramer-Morales(Kimberl... PLoS One 2016-08-09

...BRCA1 and BRCA2 inactivating mutations. Molecular docking was used to screen two chemical libraries: 1) 1,217 FDA approv...

Artificial neural network-based exploration of gene-nutrient interactions in ...

Naushad(Shaik Mohammad),Ramaiah(M Janaki),... Gene 2016-06-29

...BRCA1. Dietary intake of folate appears to confer protection against breast cancer through its modulating effects on ER ...

Risk-reducing, conservative mastectomy-analysis of surgical outcome and quali...

Rezai(Mahdi),Strauß(Stefanie),Kimmig(Raine... Gland Surg 2016-02-09

...BRCA1/2-mutation) in 30 patients and contralateral alignment in 1 patient. TiLoop(®) Bra was used in 78 and corial flap ...

Conservative mastectomies for breast cancer and risk-reducing surgery: the Me...

Manning(Aidan T),Sacchini(Virgilio S) Gland Surg 2016-02-09

...BRCA1 or BRCA2 germline mutation, or a genetic variant of uncertain significance. There was an incidental finding of duc...

Synergistic Effect of Trabectedin and Olaparib Combination Regimen in Breast ...

Ávila-Arroyo(Sonia),Nuñez(Gema Santamaría)... J Breast Cancer 2016-01-15

...BRCA1-positive breast tumor cells.,We have evaluated the in vitro synergistic effect of combinations of trabectedin and ...

Risk of Second Primary Malignancy in Breast Cancer Survivors: A Nested Popula...

Marcheselli(Raffaella),Marcheselli(Luigi),... J Breast Cancer 2016-01-15

...BRCA1 or BRCA2 mutation, human epidermal growth factor receptor 2 (HER2)+ status, chemotherapy, and radiotherapy were re...

Association of polymorphisms with a family history of cancer and the presence...

Fernandes(Gabriela C),Michelli(Rodrigo A D... Hered Cancer Clin Pract 2016-01-15

...BRCA1/2 genes; Group 2: women with variants of uncertain significance in BRCA1/2 and Group 3: women with no mutations in...

Hormone replacement therapy after menopause and risk of breast cancer in BRCA...

Kotsopoulos(Joanne),Huzarski(Tomasz),Gronw... Breast Cancer Res Treat 2016-10-14

Many BRCA1 mutation carriers undergo elective surgical oophorectomy (often before menopause) to manage their elevated ri...

Investigating the effect of 28 BRCA1 and BRCA2 mutations on their related tra...

Quiles(Francisco),Menéndez(Mireia),Tornero... Breast Cancer Res Treat 2016-10-14

Germline inactivating mutations in the BRCA1 and BRCA2 genes are responsible for hereditary breast and ovarian cancer sy...

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