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Prophylactic salpingo-oophorectomy in BRCA1 mutation carriers and postoperati...

Menkiszak(Janusz),Chudecka-Głaz(Anita),Gro... J Ovarian Res 2016-10-11

...BRCA1/BRCA2 carriers.,One hundred ninety-five patients, carriers of one of three most common mutations of the BRCA1 gene...

Genetic suppression reveals DNA repair-independent antagonism between BRCA1 a...

Nair(Sreejith J),Zhang(Xiaowen),Chiang(Hua... Nat Commun 2016-07-20

...BRCA1 is well known for its function in double-strand break (DSB) DNA repair. While BRCA1 is also implicated in transcri...

Synergetic Effects of PARP Inhibitor AZD2281 and Cisplatin in Oral Squamous C...

Yasukawa(Masaaki),Fujihara(Hisako),Fujimor... Int J Mol Sci 2016-11-04

...BRCA1/2 mutated breast and ovarian cancers, or certain solid cancers in combination with anti-cancer drugs. However, the...

Molecular Docking of Bioactive Compounds Against BRCA and COX Proteins.

Prog Drug Res 2016-04-08

...BRCA1 or BRCA2 genes and COX proteins is carefully texted in this chapter to check docking of the best inhibitor molecul...

Metastasis of Pregnancy-Associated Breast Cancer (Suspected to Be Hereditary ...

Okuda(Tomohiro),Yamamoto(Sakura),Matsuo(Se... Case Rep Obstet Gynecol 2016-03-16

...BRCA1/2, though genetic counseling was provided. In cases of pregnancy-related breast cancer, consideration must be give...

Frequency of Germline Mutations in 25 Cancer Susceptibility Genes in a Sequen...

Tung(Nadine),Lin(Nancy U),Kidd(John),Allen... J Clin Oncol 2016-11-10

Testing for germline mutations in BRCA1/2 is standard for select patients with breast cancer to guide clinical managemen...

RNF8 E3 Ubiquitin Ligase Stimulates Ubc13 E2 Conjugating Activity That Is Ess...

Hodge(Curtis D),Ismail(Ismail H),Edwards(R... J Biol Chem 2016-11-10

...BRCA1. Chromatin-targeted RNF168 rescues 53BP1 recruitment involved in non-homologous end joining but not BRCA1 recruitm...

NBR1 enables autophagy-dependent focal adhesion turnover.

Kenific(Candia M),Stehbens(Samantha J),Gol... J Cell Biol 2016-07-11

...BRCA1 (NBR1) as a key mediator of autophagy-dependent FA remodeling. NBR1 depletion impairs FA turnover and decreases ta...

A Case of Metaplastic Breast Cancer with Prolonged Response to Single Agent L...

Hamad(Lamya),Khoury(Thaer),Vona(Karen),Nes... Cureus 2016-02-26

...BRCA1 gene. Approximately seven months after a left mastectomy, the patient presented with biopsy-proven metastatic dise...

Prolactin inhibits a major tumor-suppressive function of wild type BRCA1.

Chen(Kuan-Hui Ethan),Walker(Ameae M) Cancer Lett 2016-08-24

...BRCA1, markedly increase the risk of breast and ovarian cancer, most breast and ovarian cancers express wild type BRCA1....

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