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Differential modulation of BRCA1 and BARD1 nuclear localisation and foci asse...

Brodie(Kirsty M),Henderson(Beric R) Cell Signal 2010-02-03

...BARD1 can shuttle between nucleus and cytoplasm. In this study, we evaluated the localisation patterns of BRCA1 and BARD...

The SUMO modification pathway is involved in the BRCA1 response to genotoxic ...

Morris(Joanna R),Boutell(Chris),Keppler(Me... Nature 2010-02-01

...BARD1 heterodimer greatly increases its ligase activity, identifying it as a SUMO-regulated ubiquitin ligase (SRUbL). Fu...

BARD1, a possible biomarker for breast and ovarian cancer.

Irminger-Finger(Irmgard) Gynecol Oncol 2010-04-19

...BARD1, a protein that interacts with the breast cancer gene product BRCA1, is a promising candidate for fulfilling these...

Negative feedback loop of BRCA1-BARD1 ubiquitin ligase on estrogen receptor a...

Dizin(Eva),Irminger-Finger(Irmgard) Int J Biochem Cell Biol 2010-06-11

...BARD1. We report that the estrogen receptor alpha is a target of the BRCA1-BARD1 ubiquitin ligase in vivo. BRCA1 and BAR...

Cancer predisposing missense and protein truncating BARD1 mutations in non-BR...

De Brakeleer(Sylvia),De Grève(Jacques),Lor... Hum Mutat 2010-10-29

...BARD1. In conclusion, we provide evidence for an increased breast cancer risk associated to specific BARD1 germline muta...

Genetic sequence variations of BRCA1-interacting genes AURKA, BAP1, BARD1 and...

Guénard(Frédéric),Labrie(Yvan),Ouellette(G... J Hum Genet 2010-02-16

...BARD1 and DHX9 genes, respectively. The allele frequency of each variant was further ascertained in a cohort of 98 healt...

Common variations in BARD1 influence susceptibility to high-risk neuroblastom...

Capasso(Mario),Devoto(Marcella),Hou(Cuipin... Nat Genet 2010-11-04

...BARD1 nonsynonymous SNPs. These data show that common variation in BARD1 contributes to the etiology of the aggressive a...

Impact of RING and BRCT domain mutations on BRCA1 protein stability, localiza...

Nelson(Andrew C),Holt(Jeffrey T) Radiat Res 2010-09-03

...BARD1 and BACH1, which are important for DNA repair. This failure occurs despite the continued ability of the RING mutan...

BARD1 and breast cancer in Poland.

Jakubowska(Anna),Cybulski(Cezary),Szymańsk... Breast Cancer Res Treat 2009-02-03

...BARD1 Cys557Ser allele and breast cancer in Poland. Furthermore, the BARD1 Cys557Ser allele does not appear to modify th...

NBA1, a new player in the Brca1 A complex, is required for DNA damage resista...

Wang(Bin),Hurov(Kristen),Hofmann(Kay),Elle... Genes Dev 2009-05-08

...Bard1, Abra1, RAP80, BRCC36, and BRE. NBA1 is required to maintain BRE and Abra1 abundance and for the recruitment of BR...

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