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Gene expression profiling reveals activation of the FA/BRCA pathway in advanc...

Balacescu(Ovidiu),Balacescu(Loredana),Tudo... BMC Cancer 2015-02-19

...BRCA1 in DNA Damage Response' was predicted to be the most significantly altered canonical pathway involved in intrinsic...

Enhanced charge transfer by gold nanoparticle at DNA modified electrode and i...

Yang(Yucai),Li(Chao),Yin(Li),Liu(Muyun),Wa... ACS Appl Mater Interfaces 2015-10-13

...BRCA1 in a 10 μL sample volume without any signal amplification process or the involvement of other synthesized complex,...

Phosphorylation of EXO1 by CDKs 1 and 2 regulates DNA end resection and repai...

Tomimatsu(Nozomi),Mukherjee(Bipasha),Cathe... Nat Commun 2015-11-02

...BRCA1. In summary, phosphorylation of EXO1 by CDKs is a novel mechanism regulating repair pathway choice.

TP53 supports basal-like differentiation of mammary epithelial cells by preve...

Munne(Pauliina M),Gu(Yuexi),Tumiati(Manuel... Sci Rep 2015-11-05

...BRCA1 restored the nucleoplasmic expression of ΔNp63. Trp53(-/-) mMECs eventually lost epithelial features resulting in ...

NUSAP1 influences the DNA damage response by controlling BRCA1 protein levels...

Kotian(Shweta),Banerjee(Tapahsama),Lockhar... Cancer Biol Ther 2015-04-15

...BRCA1 protein levels, and BRCA1 overexpression from a plasmid mitigates the defective phenotypes seen upon NUSAP1 deplet...

BRCA1/2 mutation carriers are potentially at higher cardiovascular risk.

Arts-de Jong(M),Maas(A H E M),Massuger(L F... Crit Rev Oncol Hematol 2015-02-09

...BRCA1) and at age 40-45 years (BRCA2) resulting in an early and abrupt menopause. BRCA1/2 mutation carriers are potentia...

Large genomic rearrangement of BRCA1 and BRCA2 genes in familial breast cance...

Cho(Ja Young),Cho(Dae-Yeon),Ahn(Sei Hyun),... Fam Cancer 2015-02-07

...BRCA1 and BRCA2 genomic rearrangements in 226 Korean familial breast cancer patients with risk factors for BRCA1 and BRC...

Invasion patterns of metastatic high-grade serous carcinoma of ovary or fallo...

Reyes(M Carolina),Arnold(Angela G),Kauff(N... Mod Pathol 2015-06-03

...BRCA1 germline mutations; 5 BRCA1 somatic mutations; 10 BRCA1 promoter methylation; 4 BRCA2 germline mutations; 1 BRCA2 ...

WRN loss induces switching of telomerase-independent mechanisms of telomere e...

Gocha(April Renee Sandy),Acharya(Samir),Gr... PLoS One 2015-01-23

...BRCA1 co-localize to APBs in VA-13 and U-2 OS, but not in Saos-2 cells. WRN loss in U-2 OS is associated with a loss of ...

A targeted next-generation sequencing assay detects a high frequency of thera...

Vasan(Neil),Yelensky(Roman),Wang(Kai),Moul... Oncologist 2015-01-12

...BRCA1/2 (n = 6, poly[ADP-ribose] polymerase inhibitors), and CCND1,2 and CCNE (n = 8)/cycline dependent kinase (CDK)6 (n...

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