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Large genomic rearrangement of BRCA1 and BRCA2 genes in familial breast cance...

Cho(Ja Young),Cho(Dae-Yeon),Ahn(Sei Hyun),... Fam Cancer 2015-02-07

...BRCA1 and BRCA2 genomic rearrangements in 226 Korean familial breast cancer patients with risk factors for BRCA1 and BRC...

Comprehensive annotation of splice junctions supports pervasive alternative s...

Colombo(Mara),Blok(Marinus J),Whiley(Phill... Hum Mol Genet 2015-02-09

...BRCA1 splicing isoforms have been described in public domain databases, but the physiological role (if any) of BRCA1 alt...

Crosstalk between ubiquitin and other post-translational modifications on chr...

Zhao(Yu),Brickner(Joshua R),Majid(Mona C),... Trends Cell Biol 2015-02-02

...BRCA1 (breast cancer 1, early onset) and 53BP1 (tumor protein p53 binding protein 1), to sites of DNA damage.

HTLV-1 Tax oncoprotein inhibits the estrogen-induced-ER α-Mediated BRCA1 expr...

Shukrun(Meital),Jabareen(Azhar),Abou-Kandi... PLoS One 2015-01-13

...BRCA1 expression by testing its influence on E2-induced expression of BRCA1 promoter-driven luciferase reporter (BRCA1-L...

BRCA1/2 mutation carriers are potentially at higher cardiovascular risk.

Arts-de Jong(M),Maas(A H E M),Massuger(L F... Crit Rev Oncol Hematol 2015-02-09

...BRCA1) and at age 40-45 years (BRCA2) resulting in an early and abrupt menopause. BRCA1/2 mutation carriers are potentia...

[Risk-adapted surveillance: focus on familial breast and ovarian cancer].

Rhiem(K),Schmutzler(R K) Bundesgesundheitsblatt Gesu... 2015-04-13

...BRCA1/2 mutations and those from high-risk families who tested negative for BRCA1/2 mutations. This program will current...

New routes to targeted therapy of intrahepatic cholangiocarcinomas revealed b...

Ross(Jeffrey S),Wang(Kai),Gay(Laurie),Al-R... Oncologist 2015-01-12

...BRCA1 (4%), BRCA2 (4%), NF1 (4%), PIK3CA (4%), PTCH1 (4%), and TSC1 (4%). Four (14%) of the ICC cases featured novel gen...

CtIP mediates replication fork recovery in a FANCD2-regulated manner.

Yeo(Jung Eun),Lee(Eu Han),Hendrickson(Eric... Hum Mol Genet 2015-02-09

...BRCA1 and MRE11, but has not been investigated as putative player in the replication stress response. Here, we identify ...

A functional cancer genomics screen identifies a druggable synthetic lethal i...

Dietlein(Felix),Thelen(Lisa),Jokic(Mladen)... Cancer Discov 2015-12-14

...BRCA1, BRCA2, ATM, PAXIP, and RAD50, as being associated with non-oncogene addiction to DNA-PKcs. Mutations in the misma...

Genome-wide transcriptome profiling of homologous recombination DNA repair.

Peng(Guang),Chun-Jen Lin(Curtis),Mo(Wei),D... Nat Commun 2015-11-02

...BRCA1 and PTEN extensively rewire the HR repair-deficient phenotype, which is found in cells with defects in either BRCA...

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