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Timing of APC/C substrate degradation is determined by fzy/fzr specificity of d…

Zur(A),Brandeis(M) EMBO J 2002-09-02

...APC/C(fzr) only. Fzy with RXXL could be degraded by APC/C(fzy) and APC/C(fzr). Interestingly, APC/C(fzy)- but not APC/C(...

Hyperaldosteronism, hypervolemia, and increased blood pressure in mice expressi…

Bhandaru(M),Kempe(DS),Rotte(A),Rexhepaj(R),K… Am J Physiol Regul Integr Com… 2009-09-00

...APC gene (apc(Min/+)), their wild-type littermates (apc(+/+)), and apc(Min/+) mice lacking functional SGK1 (apc(Min/+)/s...

The C-terminal domain of the adenomatous polyposis coli (Apc) protein is involv…

Yokoyama(A),Nomura(R),Kurosumi(M),Shimomura(… Med Mol Morphol 2011-12-00

...Apc, we have investigated Apc ( 1638T/1638T )...

Association between wild type and mutant APC gene products.

Su(LK),Johnson(KA),Smith(KJ),Hill(DE),Vogels… Cancer Res 1993-06-15

...APC are sufficient for APC oligomerization and that the first 45 amino acids of APC is necessary for this interaction. T...

APC promoter hypermethylation contributes to the loss of APC expression in colo…

Arnold(CN),Goel(A),Niedzwiecki(D),Dowell(JM)… Cancer Biol Ther 2004-10-00

...APC promoter influences APC silencing. Here we examined the influence of APC methylation on APC expression in tumors wit...

A knock-in mouse model reveals roles for nuclear Apc in cell proliferation, Wnt…

Zeineldin(M),Cunningham(J),McGuinness(W),All… Oncogene 2012-05-10

...Apc (Apc(mNLS)). Apc(mNLS/mNLS) mice are viable and fractionation of mouse embryonic fibroblasts (MEFs) isolated from th...

Purification of the adenomatous polyposis coli (APC) gene product.

Bhattacharya(G),Abraham(CA),Wildrick(DM),Bom… Arch Biochem Biophys 1995-11-10

...APC function, we purified the APC protein. To purify the full-length APC protein, HCT116 human colon cancer cells were l...

Molecular mechanisms of APC/C release from spindle assembly checkpoint inhibiti…

Yatskevich(S),Kroonen(JS),Alfieri(C),Tischer… Cell Rep 2021-00-30

...APC/C causes a substantial rearrangement of the WHB domain of APC/C's cullin subunit (APC2WHB). Although APC/CCdc20 SUMO...

Novel association of APC with intermediate filaments identified using a new ver…

Wang(Y),Azuma(Y),Friedman(DB),Coffey(RJ),Neu… BMC Cell Biol 2009-10-21

...APC antibodies have limited the exploration of APC function. APC is implicated in spindle formation by direct interactio...

Clinical Variables Associated with Pre-Fontan Aortopulmonary Collateral Burden.

Segar(DE),Pan(AY),McLennan(DI),Kindel(SJ),Ha… Pediatr Cardiol 2023-01-00

...APC flow (APC/QAo: 26.9, [22.0, 39.1]%; APC/QPV: 39.4 [33.3, 46.9]%), but to varying degrees (APC/QAo: range 11.9-44.4%;...

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