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Deficiency of APPL1 in mice impairs glucose-stimulated insulin secretion throug…

Wang(C),Li(X),Mu(K),Li(L),Wang(S),Zhu(Y),Zha… Diabetologia 2013-09-00

...APPL1) is an adapter protein that positively mediates adiponectin signalling. Deficiency of APPL1 in the target tissues ...

Resistance training recovers attenuated APPL1 expression and improves insulin-i…

Kido(K),Ato(S),Yokokawa(T),Sato(K),Fujita(S) Am J Physiol Endocrinol Metab 2018-00-01

...APPL1) has been reported as a positive regulator of insulin-stimulated Akt activation. The expression of APPL1 is reduce...

APPL1 knockdown blocks adipogenic differentiation and promotes adipocyte lipoly…

Wen(Z),Tang(Z),Li(M),Zhang(Y),Li(J),Cao(Y),Z… Mol Cell Endocrinol 2020-00-15

...APPL1 on adipogenic differentiation and adipocyte lipolysis. In this study, APPL1's function in adipocyte differentiatio...

An APPL1/Akt signaling complex regulates dendritic spine and synapse formation …

Majumdar(D),Nebhan(CA),Hu(L),Anderson(B),Web… Mol Cell Neurosci 2011-03-00

...APPL1. Expression of exogenous APPL1 increased the spine and synaptic density and the amount of surface GluR1-containing...

APPL1 promotes the migration of gastric cancer cells by regulating Akt2 phospho…

Liu(Y),Zhang(C),Zhao(L),Du(N),Hou(N),Song(T)… Int J Oncol 2017-10-00

...APPL1 in gastric carcinoma and the function in regulating cell migration. We investigated the expression of APPL1 in gas...

Appl1 and Appl2 are Expendable for Mouse Development But Are Essential for HGF-…

Tan(Y),Xin(X),Coffey(FJ),Wiest(DL),Dong(LQ),… J Cell Physiol 2016-05-00

...Appl1 and Appl2 have been implicated in multiple cellular activities, we and others have found that Appl1 is dispensable...

PTB domain and leucine zipper motif 1 (APPL1) inhibits myocardial ischemia/hypo…

Bai(L),Yang(J),Zhang(H),Liao(W),Cen(Y) Bioengineered 2021-00-00

...APPL1) is a significant factor for the progression of myocardial injury. However, the role of APPL1 in myocardial ischem...

APPL1 counteracts obesity-induced vascular insulin resistance and endothelial d…

Wang(Y),Cheng(KK),Lam(KS),Wu(D),Wang(Y),Huan… Diabetes 2011-11-00

...APPL1 in modulating vascular actions of insulin in mice and in endothelial cells. Both APPL1 knockout mice and APPL1 tra...

Appl1 is dispensable for mouse development, and loss of Appl1 has growth factor…

Tan(Y),You(H),Wu(C),Altomare(DA),Testa(JR) J Biol Chem 2010-02-26

...Appl1 in vivo, we generated Appl1 knock-out mice. Here we report that Appl1 knock-out mice are viable and fertile. Appl1...

[APPL1-mediated effects of leptin on activity of GSK-3β in C2C12 cell].

Xu(M),Xiao(YY),Han(JF),Yin(J),Lu(JX),Liu(RB)… Zhonghua Yi Xue Za Zhi 2013-05-14

...APPL1-suppressed C2C12 myotube while that of APPL1 at phospho-APPL1 (ser-401) determined in GSK-3β overexpressed/inhibit...

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