Lin(DC),Quevedo(C),Brewer(NE),Bell(A),Testa(… Mol Cell Biol 2006-12-00

...APPL1. This interaction provides a means through which APPL1 may be recruited to TrkA. In addition, the APPL1 PTB domain...

Liu(M),Zhou(L),Wei(L),Villarreal(R),Yang(X),… J Biol Chem 2012-07-27

...APPL1 phosphorylation at Ser(430) in insulin signaling, overexpression of APPL1(S430D) but not APPL1(S430A) impairs the ...

Tan(Y),You(H),Coffey(FJ),Wiest(DL),Testa(JR) Genesis 2010-09-00

...Appl1 gene was disrupted using gene trap methodology. Homozygous Appl1 knockout mice with ubiquitous loss of Appl1 prote...

Saito(T),Jones(CC),Huang(S),Czech(MP),Pilch(… J Biol Chem 2007-11-02

...APPL1 or an N- or a C-terminal APPL1 construct. Interestingly, expression of full-length APPL1 and its N terminus suppre...

Lee(JR),Hahn(HS),Kim(YH),Nguyen(HH),Yang(JM)… Biochem Biophys Res Commun 2011-11-11

...APPL1 enhances EGFR stabilization while APPL1 depletion by siRNA reduces EGFR protein levels. APPL1 depletion accelerate...

Banach-Orlowska(M),Pilecka(I),Torun(A),Pyrzy… Biochem J 2009-10-12

...APPL1-NuRD interactions, which in turn modulates the nucleocytoplasmic distribution of APPL1. Increased binding of APPL1...

Yuan(W),Liu(W),Zhang(Y),Wang(X),Xu(C),Li(Q),… J Biol Chem 2023-00-00

...APPL1 in the osteogenic differentiation of MSCs remains unclear. This study aimed to investigate the role of APPL1 in th...

Nechamen(CA),Thomas(RM),Dias(JA) Mol Cell Endocrinol 2007-01-02

...APPL1 or with APPL2. Though APPL1 and APPL2 show some similarity in primary sequence, APPL1 associates with Akt2, wherea...

Pilecka(I),Sadowski(L),Kalaidzidis(Y),Miaczy… Exp Cell Res 2011-05-01

...APPL1, and the ubiquitin molecules attached to APPL1 are linked through lysine-63. Taken together, these results add APP...

Banach-Orlowska(M),Szymanska(E),Miaczynska(M) FEBS Lett 2015-02-13

...APPL1 interacts with Dvl2, a protein known to activate the canonical and non-canonical Wnt pathways. APPL1 synergizes wi...