King(GJ),Stöckli(J),Hu(SH),Winnen(B),Duprez(… J Biol Chem 2012-11-30

...APPL2. Here, we report the crystal structure and low resolution solution structure of the BARPH domains of APPL2. We ide...

Yeo(JC),Wall(AA),Luo(L),Stow(JL) Mol Biol Cell 2015-03-01

...APPL2. siRNA depletion of either Rab31 or APPL2 reduces FcγR-mediated phagocytosis. Mechanistically, this corresponds wi...

Wang(C),Xin(X),Xiang(R),Ramos(FJ),Liu(M),Lee… J Biol Chem 2009-11-13

...APPL2, an isoform of APPL1 that forms a dimer with APPL1, can interacts with both AdipoR1 and AdipoR2 and acts as a nega...

Li(Z),Chen(Z),Zhao(L),Sun(J),Yin(L),Jiang(Y)… Genes (Basel) 2024-05-22

...APPL2, an adaptor protein, is significantly reduced in the major organs of aged mice. Knocking down APPL2 causes prematu...

Chen(Y),Zhang(W),Chen(B),Liu(Y),Dong(Y),Xu(A… Biochem J 2020-12-01

...APPL2 homodimer. The data suggest that the APPL1 BAR-PH homodimer, APPL2 BAR-PH homodimer and APPL1/APPL2 BAR-PH heterod...

Barbieri(M),Esposito(A),Angellotti(E),Rizzo(… PLoS One 2013-00-00

...APPL2 are adaptor proteins that interact with the intracellular region of adiponectin receptors and mediate adiponectin ...

Jiang(S),Fang(Q),Yu(W),Zhang(R),Hu(C),Dong(K… BMC Med Genet 2012-03-30

...APPL2 and metabolic traits remains unknown. In the current study, we aimed to test the impacts of APPL2 genetic variants...

Ryu(J),Hadley(JT),Li(Z),Dong(F),Xu(H),Xin(X)… Diabetes 2021-00-00

...APPL2 hepatocyte-specific KO mice were largely reversed by knocking out adiponectin. Mechanistically, hepatocyte APPL2 d...

Yousefi(F),Najafi(H),Behmanesh(M),Soltani(BM) Mol Biol Rep 2022-05-00

...APPL2. Two distinct tests, downregulation of APPL2 mRNA by using shRNA and Wnt signaling inhibition by using small molec...

Chial(HJ),Lenart(P),Chen(YQ) PLoS One 2010-08-30

...APPL2-APPL2) and heterotypic (i.e., APPL1-APPL2) manner on curved cell membranes. Furthermore, the results of our experi...