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Accelerated mutator phenotype in a clinical Aspergillus fumigatus isolate contr…

Song(Y),Hokken(MWJ),Zoll(J),Venselaar(H),Ver… Emerg Microbes Infect 2026-12-00

...mre11, a gene critical for genomic stability during DNA replication, is responsible for this elevated mutation rate. Mut...

Distinct Association of MRE11 and ATM Co-Expression with Clinical Outcomes in L…

Pechacova(Z),Lohynska(R),Spurkova(Z),Sedivec… Oncology 2026-03-17

Radiotherapy is a cornerstone of laryngeal cancer treatment. MRE11, a key component of the MRN complex, and the ATM prot...

Microhomology-mediated end joining acts directly on replication forks to repair…

Li(S),Zhao(Y),Li(Y),Shah(SB),Shi(Y),Nguyen(T… Mol Cell 2026-04-02

...MRE11/CtIP-mediated end resection, relies on RPA, and produces asymmetric deletion patterns, distinct from canonical MME...

BTAF1: a key regulator of DNA end resection and predictor of chemotherapy sensi…

Xie(JJ),Lin(JL),Xiang(ZC),Qu(CH),Cai(XX),Nie… Cell Death Differ 2026-03-17

...MRE11. BTAF1 loss impairs DNA end resection, sensitizing cells to genotoxic agents. The BTAF1-MRE11 interaction is regul...

DisTAL-Seq: A TALEN-specific adaptation of DISCOVER-Seq for off-target profilin…

Kobel(L),Van de Venn(L),Schröder(M),Bechter(… Mol Ther Nucleic Acids 2026-06-16

...MRE11 recruitment to double-strand breaks (DSBs). Based on the DISCOVER-Seq principle, DisTAL-Seq incorporates alignment...

Targeting lactate with a GLUT1 inhibitor reverses PARP inhibitor resistance in …

Nie(S),Pu(C),Liu(H),Pei(X),Wang(Y),Lu(X),Che… Acta Biochim Biophys Sin (Sha… 2026-05-26

...MRE11. These findings establish lactate as a key mediator of PARPi resistance and propose targeting lactate metabolism a...

Viral manipulation of DNA damage response signaling: molecular mechanisms and t…

Song(M),Wang(S),Fei(X),Guo(G) Virol Sin 2026-08-26

...MRE11 or inhibiting PARP7). Bridging molecular insights with clinical translation, this review positions DDR targeting a...

Association of DNA damage response gene polymorphisms with treatment response a…

Zhang(A),Wu(H),Liu(W),Ma(D) J Cancer None

...MRE11 rs2155209 TC/CC genotypes were protective against hyperleukocytosis and associated with longer OS, while NBS1 rs18...

Nucleostemin promotes RAD51 filament assembly on double-stranded DNA to protect…

Chang(CC),Tsai(SS),Chou(CL),Chang(YH),Hung(C… Nucleic Acids Res 2026-08-10

...MRE11-mediated degradation. Through biochemical reconstitution and single-molecule fluorescence resonance energy transfe...

Simplifying Multiplex Genome Engineering in Saccharomyces cerevisiae with Intro…

Harrison(FS),Kelso(PA),Carpenter(AC),Hawthor… FEMS Yeast Res 2026-08-20

...MRE11, and RAD59. To demonstrate how our system can be used for single transformation phenotype engineering of multiple ...

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