...mre11, a gene critical for genomic stability during DNA replication, is responsible for this elevated mutation rate. Mut...
Radiotherapy is a cornerstone of laryngeal cancer treatment. MRE11, a key component of the MRN complex, and the ATM prot...
...MRE11/CtIP-mediated end resection, relies on RPA, and produces asymmetric deletion patterns, distinct from canonical MME...
...MRE11. BTAF1 loss impairs DNA end resection, sensitizing cells to genotoxic agents. The BTAF1-MRE11 interaction is regul...
...MRE11 recruitment to double-strand breaks (DSBs). Based on the DISCOVER-Seq principle, DisTAL-Seq incorporates alignment...
...MRE11. These findings establish lactate as a key mediator of PARPi resistance and propose targeting lactate metabolism a...
...MRE11 or inhibiting PARP7). Bridging molecular insights with clinical translation, this review positions DDR targeting a...
...MRE11 rs2155209 TC/CC genotypes were protective against hyperleukocytosis and associated with longer OS, while NBS1 rs18...
...MRE11-mediated degradation. Through biochemical reconstitution and single-molecule fluorescence resonance energy transfe...
...MRE11, and RAD59. To demonstrate how our system can be used for single transformation phenotype engineering of multiple ...
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