Literature Search

Cylwik(D),Dwornik(R),Białkowska(K) Cancers (Basel) 2026-01-23

...MRE11, RAD51, and 9p22.2. The analysis identified 11 variants affecting both BRCA1 and BRCA2 carriers, most of which inc...

Hale(A),Lynch(KA),Dhoonmoon(A),Nicolae(CM),M… NAR Cancer 2026-03-00

...MRE11 recruitment to reversed replication forks to promote their degradation. This results in genomic instability in BRC...

Lukaszewicz(A),Wilson(TE),Kim(S),Keeney(S),J… bioRxiv 2026-02-15

...MRE11-deficient mouse spermatocytes, which do not resect their DSBs, deletions at double cuts occur readily, with end-jo...

Wu(H),Zhang(J),Yu(Y),Wang(W),Huang(J),Lin(Z)… Cancer Lett 2026-05-01

...MRE11-RAD50-NBS1 complex assembly, and augmenting HR-mediated DNA repair. Enhanced repair efficiency limits cytosolic DN...

Aird(EJ),Serrano-Benitez(A),Siegner(SM),Cann… Nat Commun 2026-02-25

...MRE11-RAD50-NBS1 (MRN)-mediated resection by binding and melting staggered DNA ends, thereby promoting accurate end join...

Nusawardhana(A),Nicolae(CM),Moldovan(GL) Nat Commun 2026-02-25

...MRE11. However, most tumors are BRCA pathway-proficient. Here, we show that EXO1 is overexpressed in a significant propo...

Sun(H),Yang(B),Wang(F),Xie(R),Chen(T),Chen(X… Gene 2026-04-15

...MRE11-RAD50-NBS1 (MRN) complex involved in DNA double-strand break repair. Merely few cases have been reported worldwide...

Lama(S),Barik(B),Is(S),Sarkar(T),Chanda(S),B… Cell Death Discov 2026-02-10

...MRE11 of the MRN complex, regulating the activation of the ATM-CHK2 signaling pathway. Cells with high levels of Ptbp2 a...

Ma(T),Wu(J),Li(S),Chen(J) Cancer Res 2026-07-22

...MRE11-RAD50-NBS1 (MRN) complex, rather than MUS81 or ERCC1/XPF, was the principal mediator of cruciform DNA processing f...

Song(Y),Hokken(MWJ),Zoll(J),Venselaar(H),Ver… Emerg Microbes Infect 2026-12-00

...mre11, a gene critical for genomic stability during DNA replication, is responsible for this elevated mutation rate. Mut...