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Improved method for the generation of double Holliday junction DNAs.

Shah Punatar(R),Ho(HN),West(SC) Anal Biochem 2026-07-00

...SLX4-MUS81-EME1-XPF-ERCC1 (SMX complex), or (ii) dissolution mediated by BLM-TopoIIIα-RMI1-RMI2 (BTRR complex). To facil...

STK11 and DNA Repair Gene Mutations Define Hereditary Subset of Middle Eastern …

Bu(R),Haqawi(W),Razzaq(EAA),Azam(S),Iqbal(K)… Int J Mol Sci 2026-03-14

...SLX4, RAD50, MSH6, POLD1 and NF1. Four patients (36.4%) carried PVs/LPVs in canonical FA pathway genes; this increased t...

Cruciform-forming AT/TA repeats are acted upon by structure-selective endonucle…

Boer(JL),Crippen(SM),Kim(AJ),Kramer(DN),Theu… Nucleic Acids Res 2026-02-24

...SLX4 nuclease scaffold. It was previously found that hairpin-forming CAG/CTG repeats move to the nuclear periphery to ma...

CHK2 regulates MUS81-dependent DSBs in response to replication stress and BRCA2…

Malacaria(E),Figlioli(C),Palma(A),Honda(M),V… Nucleic Acids Res 2026-08-10

...SLX4 in S-phase. At deprotected forks, in BRCA2-depleted cells, the CHK2-MUS81 complex assembles downstream of fork reve...

Scutellarin as a specific GEN1 inhibitor synergizes with olaparib to induce syn…

Zhan(B),Zhong(Y),Chen(X),Dai(Y),Du(L),Lin(Z)… Bioorg Chem 2026-08-18

...SLX4 and MUS81-EME1. Mechanistic studies showed that SCU does not disrupt GEN1-DNA binding but instead binds to the cata...

Secoemestrin C exerts rapid and prominent anti-breast cancer effect in triple-n…

Zhao(XJ),Xu(Y),Zhang(CH),Zhao(C),Liu(L),Wang… Acta Pharmacol Sin 2026-05-00

...SLX4 as an oncogene promoting breast cancer development, potentially by stabilizing mtDNA to suppress pathologic mitocho...

Cruciform-forming AT/TA repeats are acted upon by structure selective endonucle…

Boer(JL),Crippen(SM),Kim(AJ),Kramer(DN),Theu… bioRxiv 2026-01-22

...SLX4 nuclease scaffold. It was previously found that hairpin forming CAG/CTG repeats move to the nuclear periphery to ma...

SenExo-cCCT2 Reprograms Senescence Response and Anti-Tumor Immunity Following F…

Zhu(S),Chen(Y),Lin(H),Lu(J),Pan(Y),Li(G),Wu(… Adv Sci (Weinh) 2025-10-00

...SLX4 condensate-mediated DNA damage repair pathways by regulating small ubiquitin-like modifier conjugation, thereby pro...

A panel incorporating genetic variants of RIN3, NLRC3, and SLX4 shows promise i…

Chen(PK),Chen(YM),Cho(CF),Chen(JJJW),Wu(JC),… Clin Exp Rheumatol 2025-09-00

...SLX4 genes that were predictive of achieving remission after tofacitinib therapy, and its results were completely consis...

TopBP1 coordinates DNA repair synthesis in mitosis via recruitment of the nucle…

Bagge(J),Petersen(KV),Karakus(SN),Nielsen(TM… Commun Biol 2025-07-04

...SLX4. Additionally, we demonstrate that the recruitment of SLX4 to TopBP1 foci in mitosis depends on TopBP1-K704, SLX4-T...

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