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Liver X receptor ligands suppress ubiquitination and degradation of LXRalpha ...

Kim(Kang Ho),Yoon(Jeong Min),Choi(A Hyun),... Mol Endocrinol 2009-05-26

...BARD1). Interestingly, LXR ligand represses ubiquitination and degradation of LXRalpha, and the interaction between LXRa...

BRCA1-associated protein 1 interferes with BRCA1/BARD1 RING heterodimer activ...

Nishikawa(Hiroyuki),Wu(Wenwen),Koike(Ayaka... Cancer Res 2009-01-30

...BARD1 is unclear. Here, we report that BAP1 interacts with BARD1 to inhibit the E3 ligase activity of BRCA1/BARD1. Domai...

Altered expression of anti-apoptotic proteins in non-involved tissue from can...

Batchelder(A J),Gordon-Weeks(A N),Walker(R A) Breast Cancer Res Treat 2009-02-17

...BARD1. All assessments were performed without knowledge as to whether it was a cancer case or control. A significant dif...

E3 ligase activity of BRCA1 is not essential for mammalian cell viability or ...

Reid(Latarsha J),Shakya(Reena),Modi(Ami P)... Proc Natl Acad Sci U S A 2009-01-27

...BARD1 protein to form a heterodimeric complex that acts as a ubiquitin E3 ligase. Because the enzymatic activity of the ...

Rapid recruitment of BRCA1 to DNA double-strand breaks is dependent on its as...

Wei(Leizhen),Lan(Li),Hong(Zehui),Yasui(Aki... Mol Cell Biol 2009-01-09

...BARD1, which binds to the N terminus of BRCA1. Two small regions in the N terminus of BRCA1 independently accumulated at...

The BARD1 Cys557Ser polymorphism and breast cancer risk: an Australian case-c...

Johnatty(Sharon E),Beesley(Jonathan),Chen(... Breast Cancer Res Treat 2009-09-30

BARD1 was first identified as a BRCA1-interacting protein with tumour-suppressor functions. Some association studies sug...

Three-cohort targeted gene screening reveals a non-synonymous TRKA polymorphi...

van Schijndel(Jessica E),van Loo(Karen M J... J Psychiatr Res 2009-12-24

...BARD1 (rs28997576), LAMA5 (rs3810548), DKK2 (rs7037102), NOD2 (rs2066844) and RELN (rs2229860), whereas protective allel...

Dynamic interactions of proteins in complex networks: identifying the complet...

Christensen(Devin E),Klevit(Rachel E) FEBS J 2009-10-22

...BARD1 can interact with 10 different E2s. The ability of BRCA1 to interact with multiple E2s is likely to be a common fe...

Ubiquitination and downregulation of BRCA1 by ubiquitin-conjugating enzyme E2...

Ueki(Tomomi),Park(Jae-Hyun),Nishidate(Tosh... Cancer Res 2009-12-15

...BARD1) complex. Knocking down of UBE2T expression with small interfering RNA drastically suppressed the growth of breast...

Distinct roles of BARD1 isoforms in mitosis: full-length BARD1 mediates Auror...

Ryser(Stephan),Dizin(Eva),Jefford(Charles ... Cancer Res 2009-03-23

...BARD1 protein isoforms, including the RING finger-deficient variant BARD1beta. Here, we show that BARD1 has BRCA1-depend...

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