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Molecular characterization of 7 new established cell lines from high grade se...

Kreuzinger(Caroline),Gamperl(Magdalena),Wo... Cancer Lett 2015-06-26

...BRCA1 and BRCA2 mutations. To conclude, we have established seven cell lines and well characterized them at genomic and ...

Evaluation of the protective effect of Nigella sativa extract and its primary...

Linjawi(Sabah A A),Khalil(Wagdy K B),Hassa... Arch Med Sci 2015-04-11

...Brca1, Brca2, Id-1 and P53 mutation) related to breast cancer in female rats induced by 7,12-dimethylbenz[a]anthracene (...

Association of type and location of BRCA1 and BRCA2 mutations with risk of br...

Rebbeck(Timothy R),Mitra(Nandita),Wan(Fei)... JAMA 2015-06-18

...BRCA1 or BRCA2 (BRCA1/2) and cancer risk exists.,To identify mutation-specific cancer risks for carriers of BRCA1/2.,Obs...

Radiation therapy in the locoregional treatment of triple-negative breast can...

Moran(Meena S) Lancet Oncol 2015-07-09

...BRCA1 and TNBC, knowledge of baseline mutation status can be useful to guide locoregional treatment decisions. TNBC is n...

[Should knowledge of BRCA1 status impact the choice of chemotherapy in metast...

Clergue(Océane),Jones(Natalie),Sévenet(Nic... Bull Cancer 2015-05-18

...BRCA1 or BRCA2 function may modify chemo-sensitivity. This literature review aims to determine whether BRCA1 mutation st...

A 12-year experience at a tertiary hospital on patients with multiple primary...

Papaconstantinou(Ioannis),Mantzos(Dionysio... J BUON 2015-04-30

...BRCA1 and BRCA2 genes. The second most common type of malignancy was colorectal cancer (24%); 5 developed 2 PMNs, wherea...

Poly (ADP-ribose) polymerase inhibitors: recent advances and future development.

Scott(Clare L),Swisher(Elizabeth M),Kaufma... J Clin Oncol 2015-06-15

...BRCA1 or BRCA2 seem to be particularly sensitive. However, it is also becoming clear that germline BRCA1/2 mutations are...

An update on PARP inhibitors for the treatment of cancer.

Benafif(Sarah),Hall(Marcia) Onco Targets Ther 2015-03-09

...BRCA1/2 mutation-related cancers. This article attempts to summarize the rationale and theory behind PARPi, the clinical...

Phase II Study of Gemcitabine, Carboplatin, and Iniparib As Neoadjuvant Thera...

Telli(Melinda L),Jensen(Kristin C),Vinayak... J Clin Oncol 2015-08-21

...BRCA1/2 mutation-associated breast cancer.,This single-arm phase II study enrolled patients with stage I to IIIA (T ≥ 1 ...

TBCRC009: A Multicenter Phase II Clinical Trial of Platinum Monotherapy With ...

Isakoff(Steven J),Mayer(Erica L),He(Lei),T... J Clin Oncol 2015-08-21

...BRCA1/2 mutations (n = 11). In patients without BRCA1/2 mutations (n = 66), exploratory analyses showed that a BRCA-like...

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