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Associations of common breast cancer susceptibility alleles with risk of brea...

Kuchenbaecker(Karoline B),Neuhausen(Susan ... Breast Cancer Res 2015-11-09

...BRCA1 and BRCA2 carriers.,We used data from 15,252 BRCA1 and 8,211 BRCA2 carriers to analyze the associations between ap...

Clinical relevance of normal and tumour cell radiosensitivity in BRCA1/BRCA2 ...

Bernier(Jacques),Poortmans(Philip) Breast 2015-12-15

Women harbouring BRCA1/2 mutations are known to be at higher lifetime risk of developing breast cancer than non-carriers...

Rac1 promotes diethylnitrosamine (DEN)-induced formation of liver tumors.

Bopp(Anita),Wartlick(Friedrich),Henninger(... Carcinogenesis 2015-06-24

...Brca1 and DNA repair protein RAD51 homolog (Rad51) and the cell cycle regulatory factor p27 was enhanced in the absence ...

Neddylation inhibits CtIP-mediated resection and regulates DNA double strand ...

Jimeno(Sonia),Fernández-Ávila(María Jesús)... Nucleic Acids Res 2015-05-01

...BRCA1 and CtIP-mediated DNA end resection, a key process in repair pathway choice. By controlling the length of ssDNA pr...

Risk-reducing salpingectomy with delayed oophorectomy in BRCA1/2 mutation car...

Arts-de Jong(Marieke),Harmsen(Marline G),H... Gynecol Oncol 2015-04-27

...BRCA1/2 mutation carriers for study participation and uniform counseling. Furthermore, most BRCA1/2 mutation carriers an...

DNA helicases FANCM and DDX11 are determinants of PARP inhibitor sensitivity.

Stoepker(Chantal),Faramarz(Atiq),Rooimans(... DNA Repair (Amst) 2015-07-17

The encouraging response rates of BRCA1- and BRCA2-mutated cancers toward PARP inhibitors make it worthwhile to identify...

Cullin 4A and 4B ubiquitin ligases interact with γ-tubulin and induce its pol...

Thirunavukarasou(Anand),Govindarajalu(Goku... Mol Cell Biochem 2015-09-29

...BRCA1 ubiquitin ligases localize on centrosome region and regulate the centrosome duplication cycle for genomic stabilit...

Role of lamin b1 in chromatin instability.

Butin-Israeli(Veronika),Adam(Stephen A),Ja... Mol Cell Biol 2015-04-17

...BRCA1 and RAD51. Taken together, the results suggest that the maintenance of lamin B1 levels is required for DNA replica...

Suppression of BRCA1 sensitizes cells to proteasome inhibitors.

Gu(Y),Bouwman(P),Greco(D),Saarela(J),Yadav... Cell Death Dis 2015-09-11

...BRCA1 by siRNA. 26S proteasome inhibitors bortezomib and carfilzomib emerged as a new class of selective BRCA1-targeting...

BRCA1 promoter hypermethylation signature for early detection of breast cance...

Truong(Phuong Kim),Lao(Thuan Duc),Doan(Tha... Asian Pac J Cancer Prev 2015-08-24

...BRCA1 gene, belonged to the tumor suppressor gene family, as the biomarker for breast cancer in Vietnamese population, s...

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