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Ubc13/Rnf8 ubiquitin ligases control foci formation of the Rap80/Abraxas/Brca...

Wang(Bin),Elledge(Stephen J) Proc Natl Acad Sci U S A 2008-01-15

...Bard1, Abraxas, Rap80, and Brcc36; however, with the exception of the Brca1-Abraxas interaction, how the A complex is as...

The 3' processing factor CstF functions in the DNA repair response.

Mirkin(Nurit),Fonseca(Danae),Mohammed(Sami... Nucleic Acids Res 2008-05-08

...BARD1 are all found at sites of repaired DNA. Our results indicate that CstF plays an active role in the response to DNA...

Cell-surface and mitotic-spindle RHAMM: moonlighting or dual oncogenic functi...

Maxwell(Christopher Alan),McCarthy(James),... J Cell Sci 2008-07-31

...BARD1; this association attenuates the mitotic-spindle-promoting activity of RHAMM that might contribute to tumor progre...

Oncogenic BARD1 isoforms expressed in gynecological cancers.

Li(Lin),Ryser(Stephan),Dizin(Eva),Pils(Die... Cancer Res 2008-01-15

...BARD1 and isoforms. Expression of NH(2) terminally truncated BARD1 was correlated with advanced stage of cancer, and exp...

BARD1 regulates BRCA1-mediated transactivation of the p21WAF1/CIP1 and Gadd45...

Fabbro(Megan),Henderson(Beric R) Cancer Lett 2008-06-24

...BARD1. Here we tested the effect of BARD1 on BRCA1 transactivation of the p21 and Gadd45 promoters. We show that BARD1 p...

Structural requirements for the BARD1 tumor suppressor in chromosomal stabili...

Laufer(Marsha),Nandula(Subhadra V),Modi(Am... J Biol Chem 2008-01-23

...BARD1 alone also contains three tandem ankyrin repeats. In normal cells, the BRCA1/BARD1 heterodimer is believed to enha...

The basal-like mammary carcinomas induced by Brca1 or Bard1 inactivation impl...

Shakya(Reena),Szabolcs(Matthias),McCarthy(... Proc Natl Acad Sci U S A 2008-05-28

...Bard1-, Brca1-, and Bard1/Brca1-mutant mice indicate that the tumor suppressor activities of both genes are mediated thr...

Re-engineering a split-GFP reassembly screen to examine RING-domain interacti...

Sarkar(Mohosin),Magliery(Thomas J) Mol Biosyst 2008-12-24

...BARD1 and the tumor suppressor BRCA1 as our test system. The wild-type interaction failed to give fluorescence with the ...

The BARD1 C-terminal domain structure and interactions with polyadenylation f...

Edwards(Ross A),Lee(Megan S),Tsutakawa(Sus... Biochemistry 2008-11-12

...BARD1 N-terminal RING domain binds BRCA1 while the BARD1 C-terminal ankyrin and tandem BRCT repeat domains bind CstF-50 ...

RAP80 and RNF8, key players in the recruitment of repair proteins to DNA dama...

Yan(Jun),Jetten(Anton M) Cancer Lett 2008-10-28

...BARD1 complex through its interaction with CCDC98 (Abraxas). The UIMs of RAP80 are critical for targeting this protein c...

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