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Phase II Study of Gemcitabine, Carboplatin, and Iniparib As Neoadjuvant Thera...

Telli(Melinda L),Jensen(Kristin C),Vinayak... J Clin Oncol 2015-08-21

...BRCA1/2 mutation-associated breast cancer.,This single-arm phase II study enrolled patients with stage I to IIIA (T ≥ 1 ...

TBCRC009: A Multicenter Phase II Clinical Trial of Platinum Monotherapy With ...

Isakoff(Steven J),Mayer(Erica L),He(Lei),T... J Clin Oncol 2015-08-21

...BRCA1/2 mutations (n = 11). In patients without BRCA1/2 mutations (n = 66), exploratory analyses showed that a BRCA-like...

Radiation therapy in the locoregional treatment of triple-negative breast can...

Moran(Meena S) Lancet Oncol 2015-07-09

...BRCA1 and TNBC, knowledge of baseline mutation status can be useful to guide locoregional treatment decisions. TNBC is n...

[Should knowledge of BRCA1 status impact the choice of chemotherapy in metast...

Clergue(Océane),Jones(Natalie),Sévenet(Nic... Bull Cancer 2015-05-18

...BRCA1 or BRCA2 function may modify chemo-sensitivity. This literature review aims to determine whether BRCA1 mutation st...

Protein stability versus function: effects of destabilizing missense mutation...

Gaboriau(David C A),Rowling(Pamela J E),Mo... Biochem J 2015-05-01

...BRCA1 (breast cancer early-onset 1) are associated with increased risk of developing breast and ovarian cancers. BRCA1 i...

Silibilin-induces apoptosis in breast cancer cells by modulating p53, p21, Ba...

Pirouzpanah(Mohammad Bagher),Sabzichi(Mehd... Asian Pac J Cancer Prev 2015-12-03

...BRCA1, BCL-X1 and ATM was analyzed. Treatment for 24h had a significant dose-dependent inhibitory effect on cell growth ...

An update on PARP inhibitors for the treatment of cancer.

Benafif(Sarah),Hall(Marcia) Onco Targets Ther 2015-03-09

...BRCA1/2 mutation-related cancers. This article attempts to summarize the rationale and theory behind PARPi, the clinical...

Mechanisms of DNA methyltransferase-inhibitor interactions: Procyanidin B2 sh...

Shilpi(Arunima),Parbin(Sabnam),Sengupta(Di... Chem Biol Interact 2015-07-03

...BRCA1. Moreover, the toxic property of procyanidin B2 towards triple negative breast cancer cells to normal cells offers...

Participation of Korean families at high risk for hereditary breast and ovari...

Sun(Young),Kang(Eunyoung),Baek(Hyunnam),Ju... Jpn J Clin Oncol 2015-08-24

...BRCA1/2 gene mutations at Seoul National University Bundang Hospital between July 2003 and September 2012.,In total, 728...

Clinical and molecular characteristics of triple-negative breast cancer patie...

Asleh-Aburaya(Karama),Fried(Georgeta) Springerplus 2015-03-31

...BRCA1/2 mutations. Median tumor size was 2 cm and positive lymph nodes were detected in pathological examination in 40 p...

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