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Biallelic mutations in BRCA1 cause a new Fanconi anemia subtype.

Sawyer(Sarah L),Tian(Lei),Kähkönen(Markett... Cancer Discov 2015-10-22

...BRCA1 mutations has precluded assignment of BRCA1 as a definitive Fanconi anemia susceptibility gene. Here, we report th...

Nicotinamide sensitizes human breast cancer cells to the cytotoxic effects of...

Domínguez-Gómez(G),Díaz-Chávez(J),Chávez-B... Oncol Rep 2015-08-20

...BRCA1 expression or function, such as BRCA1‑deficient MDA-MB-436 cells, low expression BRCA1 MCF-7 cells, and the BRCA1 ...

Hereditary cancer-associated mutations in women diagnosed with two primary ca...

Saam(Jennifer),Moyes(Kelsey),Landon(Michel... Oncology 2015-06-11

...BRCA1 or BRCA2 mutation. Among women with both colorectal and ovarian cancer, 28.1% (264/941) had a mutation associated ...

Carboplatin and taxol resistance develops more rapidly in functional BRCA1 co...

Busschots(Steven),O'Toole(Sharon),O'Leary(... Exp Cell Res 2015-10-08

...BRCA1-wildtype) compared to OVCAR8 (BRCA1-methylated). Alternating carboplatin and taxol treatment delayed but did not p...

Clinical management of women at high risk of breast cancer.

Wuttke(Melanie),Phillips(Kelly-Anne) Curr Opin Obstet Gynecol 2015-08-31

...BRCA1 and BRCA2. Several observational studies have suggested that contralateral risk-reducing mastectomy, following a d...

Next-generation sequencing for hereditary breast and gynecologic cancer risk ...

Kurian(Allison W),Kingham(Kerry E),Ford(Ja... Curr Opin Obstet Gynecol 2015-08-31

...BRCA1/2 among patients who meet evidence-based practice guidelines for BRCA1/2 testing, with a high rate (15-88%) of uni...

Elevated estrogen receptor-α in VHL-deficient condition induces microtubule o...

Jung(Youn-Sang),Chun(Ho-Young),Yoon(Min-Ho... Neoplasia 2015-08-20

...BRCA1-Rad51 interaction. In fact, numerous MTOC in VHL- or BRCA1-deficient cells are reduced by Fulvestrant, inhibitor o...

Germline mutations of DICER1 in Chinese women with BRCA1/BRCA2-negative famil...

Cao(W-M),Gao(Y),Yang(H-J),Xie(S-N),Meng(X-... Genet Mol Res 2015-10-26

...BRCA1/BRCA2-negative Chinese breast cancer families were screened for germline mutations in DICER1. In addition, 100 unr...

Incidental nonuterine high-grade serous carcinomas arise in the fallopian tub...

Gilks(C Blake),Irving(Julie),Köbel(Martin)... Am J Surg Pathol 2015-04-09

...BRCA1/2 mutation, arise in the fimbria of the fallopian tube. However, the site of origin of sporadic HGSC, which is usu...

Incidental serous tubal intraepithelial carcinoma and early invasive serous c...

Morrison(Jane C),Blanco(Luis Z),Vang(Russe... Am J Surg Pathol 2015-05-12

...BRCA1 and BRCA2 and in cases of pelvic high-grade serous carcinoma. Data on incidental STICs and clinically occult micro...

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