BRCA1 and BRCA2 genes are critical in homologous recombination DNA repair and have been implicated in familial breast an...
...BRCA1 germline mutation carriers (approximately 80%), and approximately 11-16% of all TNBCs harbor BRCA1 or BRCA2 germli...
...BRCA1. Depletion of both 53BP1 and BRCA1 increases repair needing microhomology usage and augments loss of DNA sequence,...
...BRCA1 and BRCA2 entire coding region as well as for founder disease-predisposing alleles in CHEK2, NBN/NBS1 and ATM gene...
...BRCA1/2 cohort and two sporadic cohorts). Controls were 62 non-CHEK2 MBC patients, matched for age at and year of primar...
...BRCA1 or BRCA2 mutations in individual patients, loss of BRCA1 promoter methylation, an alteration in molecular subtype,...
...BRCA1 proteins, suggesting that BAP1 may promote DNA repair partly through stabilizing BRCA1. Furthermore, using the MM ...
...BRCA1 gene, which could be a cancer-causing variant based on the functional study of Lee et al. (2010) and our current p...
Several studies have evaluated histologic features of non-neoplastic breast parenchyma in patients with BRCA1/2 mutation...
...BRCA1 and BRCA2 genetic mutations are known to result in an elevated breast cancer risk. Routine BRCA1/2 gene screening ...
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