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A machine learning framework for predictive interpretation of variants of unc...

Nizamuddin(N),Biswas(S),Zawar(A),Deshpande... Front Syst Biol None

...BRCA1/BRCA2 variants from the BRCA Exchange database, completely independent of the ClinVar training data demonstrated a...

Dual germline BRCA and mismatch-repair mutations: a narrative review.

Chen(R),Ge(C),Yuan(F),Fu(K),Long(X),Wu(K),... Expert Rev Mol Diagn 2026-08-21

...BRCA1/2 variant with a pathogenic mismatch-repair (MMR) variant, but current guidelines manage the two inherited pathway...

Abexinostat attenuates temozolomide-resistant glioma stem cells.

Perumalsamy(B),Vengoji(R),Thiraviyam(A),Ra... Neuro Oncol 2026-08-19

...BRCA1) and stemness (CD44, KLF4, c-Myc, and BMI1) revealed Abx decreased chromatin accessibility. Abx decreased stem cel...

From genetic testing to prevention: an integrated clinical pathway for heredi...

Viveros-Carreño(D),Mora-Soto(N),Beshar(I),... Int J Gynecol Cancer 2026-08-03

Hereditary tubo-ovarian cancer risk assessment has evolved from a BRCA1/2-centered consultation to an integrated prevent...

Immunophenotyping and Molecular Patterns of Prostate Cancer in East Africa: D...

Posite(CM),Wabinga(H),Atwine(R),Vahwere(BM... Clin Genitourin Cancer 2026-07-28

...BRCA1/2 was noted in high-grade tumors. All included studies demonstrated a low risk of bias, though confounding managem...

Genomic landscape of ERCC alterations in breast and gynecological cancers: im...

Canbek(S),Karaağaç(M),Ermiş(A),Türkan(Ş),T... Mol Biol Rep 2026-08-21

...BRCA1/2, the study analyzed tumor characteristics, metastatic status, and receptor expression in patients harboring ERCC...

Functional phosphoproteomic analysis of SMG1 in nonsense-mediated mRNA decay ...

Pai(AKA),Dcunha(L),Gopalakrishnan(AP),Umma... Front Syst Biol None

...BRCA1, RAD51AP1, NBN, PNKP, TP53BP1, and PBRM1. UALCAN analysis further revealed differential regulation of SMG1 phospho...

Unusual Presentation of Triple-Negative Breast Cancer in a Young Woman with X...

Alsaati(B),Ujaimi(R),Trabulsi(N),Abusanad(... Case Rep Oncol None

...BRCA1/2 testing was negative. She underwent four cycles of neoadjuvant doxorubicin/cyclophosphamide with limited respons...

Scutellarin as a specific GEN1 inhibitor synergizes with olaparib to induce s...

Zhan(B),Zhong(Y),Chen(X),Dai(Y),Du(L),Lin(... Bioorg Chem 2026-08-18

...BRCA1/2-mutant tumors, has emerged as an effective strategy for cancer therapy. GEN1, a structure-selective endonuclease...

Integrated Genomic and Immune Profiling of Early Onset Lung Cancer in East As...

Wang(J),Lu(Z),Ge(M),Zhang(X),Chen(D),Peng(... Clin Lung Cancer 2026-07-27

...BRCA1 being particularly prominent. Immunologically, LOLC tumors exhibited higher TMB and PD-L1 positivity. Integrated p...

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