...BRCA1 and BRCA2 mutant and three BRCA1 and BRCA2 wild-type (WT) patient-derived pancreatic cancer xenografts.,We observe...
...BRCA1; 3 BRCA2). TRAEs were mostly haematological and most prominent shortly after switching from combination to monothe...
The contribution of BRCA1 mutations to both hereditary and sporadic breast and ovarian cancer (HBOC) has not yet been th...
Veliparib is a potent small molecule inhibitor of PARP-1/2, which is cytotoxic in tumor cells with deficiencies in BRCA1...
...BRCA1-associated protein 1 (BAP1) gene and germline BAP1 mutations predispose to malignant pleural mesothelioma (MPM). O...
...BRCA1 were discovered and deemed as the first genetic predisposition for the disease in 1994. By now, genetic predisposi...
...BRCA1 related breast cancers. Management of these tumours is a challenge to the clinician because of its aggressive beha...
...BRCA1/2 gene mutation and others with a high breast cancer risk may opt for bilateral prophylactic mastectomy. To allow ...
...BRCA1, BRCA2 mutations, and also due to new staging standards and use of nuclear magnetic resonance. This increase in th...
...BRCA1 splice-site mutation, and another, a recurrent BRCA2 nonsense mutation, both of germline origin. The novel BRCA1 m...
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