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Mutational landscape of the essential autophagy gene BECN1 in human cancers.

Laddha(Saurabh V),Ganesan(Shridar),Chan(Ch... Mol Cancer Res 2015-02-19

...BRCA1 and BECN1, and deletions of only BRCA1 but not BECN1, were found in breast and ovarian cancers, consistent with BR...

Effects of BRCA1- and BRCA2-related mutations on ovarian and breast cancer su...

Zhong(Qian),Peng(Hong-Ling),Zhao(Xia),Zhan... Clin Cancer Res 2015-09-21

...BRCA1 and BRCA2 mutation carriers had better OS (HR, 0.76; 95% CI, 0.70-0.83 for BRCA1 mutation carriers; HR, 0.58; 95% ...

Mutational analysis of BRCA1/2 in a group of 134 consecutive ovarian cancer p...

Ratajska(Magdalena),Krygier(Magdalena),Stu... J Appl Genet 2015-07-22

...BRCA1 alterations included in the standard diagnostic panel in northern Poland. However, the remaining seven BRCA1/2 mut...

Olaparib monotherapy in patients with advanced cancer and a germline BRCA1/2 ...

Kaufman(Bella),Shapira-Frommer(Ronnie),Sch... J Clin Oncol 2015-03-16

...BRCA1 and BRCA2 (BRCA1/2) -associated breast and ovarian cancers. We evaluated the efficacy and safety of olaparib in a ...

DNA repair gene polymorphisms and clinical outcome of patients with primary s...

Zhou(Qiang),Zou(Bing-Wen),Xu(Yong),Xue(Jia... Tumour Biol 2015-06-15

...BRCA1-Lys1183Arg, and BRCA2-Asn372His) and the clinical outcome of patients with primary small cell carcinoma of esophag...

Breast cancer following ovarian cancer in BRCA mutation carriers.

Gangi(Alexandra),Cass(Ilana),Paik(Daniel),... JAMA Surg 2015-03-24

...BRCA1 or BRCA2 mutation. The mean age of patients at diagnosis of EOC was 49.5 years (range, 28-89 years). Of the 135 pa...

[Progress in the effects of BRAP gene on cardiovascular diseases].

Lv(Duo),Zhu(Yi-min) Zhejiang Da Xue Xue Bao Yi ... 2015-07-26

...BRCA1 associated protein) is one of BRCA1 (Breast cancer suppressor protein) associated cytoplasmic proteins. BRAP gene ...

Estimate of the penetrance of BRCA mutation and the COS software for the asse...

Berrino(Jacopo),Berrino(Franco),Francisci(... Fam Cancer 2015-12-30

...BRCA1 and 229 BRCA2 mutated families. We tested the COS performance in 436 Italian breast/ovarian cancer families includ...

A recessive variant of XRCC4 predisposes to non- BRCA1/2 breast cancer in chi...

He(Min),Hu(Xin),Chen(Li),Cao(A-Yong),Yu(Ke... Oncotarget 2015-10-01

...BRCA1/2 breast cancer patients and 1,623 cancer-free controls, we investigated the contribution of genetic variants of X...

RNA-seq profiling of a radiation resistant and radiation sensitive prostate c...

Young(Arabella),Berry(Rachael),Holloway(Ad... BMC Cancer 2015-07-09

...BRCA1, RAD51, FANCG, MCM7, CDC6 and ORC1 were identified as being significantly differentially regulated post-irradiatio...

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