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TP53 BRCA1 CRISPR single-cell cancer

Lu(Daoyuan),Cai(Huan),Park(Sung-Soo),Siddi... Mol Cell Biol 2015-05-26

...BRCA1 in repair complexes; upregulation of repair proteins, including HMGN1 and RFC1; and regulation of poly(ADP-ribose)...

Cloud(Ann J),Thai(Ashley),Liao(Yuyan),Terr... Breast Cancer Res Treat 2015-09-28

...BRCA1 and/or BRCA2 carriers [HR 0.39, 95 % CI (0.16-0.97)]}. These results support that women at high risk, similar to w...

Ward(Ambber),Khanna(Kum Kum),Wiegmans(Adri... Cancer Treat Rev 2015-02-19

...BRCA1 functional loss and PARP inhibition. In this review we suggest that clinical outcomes could be improved by additio...

Economopoulou(P),Dimitriadis(G),Psyrri(A) Cancer Treat Rev 2015-02-19

...BRCA1/2 mutations. During the past few years and thanks to technology evolution, we have been witnesses of an intensive ...

Molina-Montes(Esther),Pérez-Nevot(Beatriz)... Breast 2015-08-24

BRCA1/2 mutation carriers are at a higher risk of breast cancer and of subsequent contralateral breast cancer (CBC). Thi...

Rusch(Andreas),Ziltener(Gabriela),Nackaert... Lung Cancer 2015-08-20

...BRCA1-associated protein 1 (BAP1) gene and germline BAP1 mutations predispose to malignant pleural mesothelioma (MPM). O...

Xu(Guotai),Chapman(J Ross),Brandsma(Inger)... Nature 2015-06-29

...BRCA1 is an important factor for this repair pathway. In the absence of BRCA1-mediated HR, the administration of PARP in...

Wang(Peng),Ning(Shangwei),Zhang(Yunpeng),L... Nucleic Acids Res 2015-07-07

...BRCA1/2-associated lncACTs were able to discriminate between two groups of patients with different clinical outcomes. Di...

Downs(Bradley),Wang(San Ming) Cancer Genet 2015-08-24

...BRCA1 is the most penetrant predisposition for the disease. Mutated BRCA1 leads to disease by causing genome instability...

Martins(Filipe C),Santiago(Ines de),Trinh(... Genome Biol 2015-08-18

...BRCA1/2 mutations are the main drivers in high-grade serous ovarian carcinoma (HGSOC). We hypothesise that combining tis...

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