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Effects of BRCA1- and BRCA2-related mutations on ovarian and breast cancer su...

Zhong(Qian),Peng(Hong-Ling),Zhao(Xia),Zhan... Clin Cancer Res 2015-09-21

...BRCA1 and BRCA2 mutation carriers had better OS (HR, 0.76; 95% CI, 0.70-0.83 for BRCA1 mutation carriers; HR, 0.58; 95% ...

Stabilization and targeting of INO80 to replication forks by BAP1 during norm...

Lee(Han-Sae),Lee(Shin-Ai),Hur(Shin-Kyoung)... Nat Commun 2015-12-15

...BRCA1-associated protein-1 (BAP1), a tumour suppressor and nuclear de-ubiquitinating enzyme that also functions to stabi...

High-resolution melting (HRM) assay for the detection of recurrent BRCA1/BRCA...

Riahi(Aouatef),Kharrat(Maher),Lariani(Imen... Fam Cancer 2015-07-21

Germline deleterious mutations in the BRCA1/BRCA2 genes are associated with an increased risk for the development of bre...

BRAT1 deficiency causes increased glucose metabolism and mitochondrial malfun...

So(Eui Young),Ouchi(Toru) BMC Cancer 2015-04-07

...BRCA1-associated ATM activator 1) interacts with both BRCA1, ATM and DNA-PKcs, and has been implicated in DNA damage res...

Predictive role of RRM1 and BRCA1 mRNA expression on the clinical outcome of ...

Liang(J G),Jin(Z Y),Gao(X D),Te(M R),Ge(L ... Genet Mol Res 2015-04-08

This study aimed to evaluate the association between RRM1 and BRCA1 expressions and the therapeutic efficacy of platinum...

Mammography screening and the risk of breast cancer in BRCA1 and BRCA2 mutati...

Giannakeas(Vasily),Lubinski(Jan),Gronwald(... Breast Cancer Res Treat 2015-09-21

...BRCA1 and BRCA2 carriers. We identified 2,346 women with a BRCA1 (n = 1844) or BRCA2 (n = 502) mutation and no breast ca...

Deregulation of the EGFR/PI3K/PTEN/Akt/mTORC1 pathway in breast cancer: possi...

Davis(Nicole M),Sokolosky(Melissa),Stadelm... Oncotarget 2015-05-12

...BRCA1, BRCA2, EGFR1, PIK3CA, PTEN, TP53, RB as well as other oncogenes and tumor suppressor genes. In some breast cancer...

Chronic treatment with cisplatin induces replication-dependent sister chromat...

Su(Wen-Pin),Hsu(Sen-Huei),Wu(Cheng-Kuei),C... Oncotarget 2015-12-21

...BRCA1, TS gene UBC13, or FA gene FANCD2 suppresses SCE and causes cells to accumulate in the S phase, concomitantly with...

Implementing a screening tool for identifying patients at risk for hereditary...

Brannon Traxler(L),Martin(Monique L),Kerbe... Ann Surg Oncol 2015-06-16

...BRCA1/2 genes were facilitated if appropriate.,Data was collected from November 2012 through December 2013, including 2,...

Molecular features of the basal-like breast cancer subtype based on BRCA1 mut...

Prat(Aleix),Cruz(Cristina),Hoadley(Katheri... Breast Cancer Res Treat 2015-09-21

...BRCA1 mutations. Fourteen patients with BRCA1-mutated (nine germline and five somatic) tumors and basal-like disease, an...

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