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TP53 BRCA1 CRISPR single-cell cancer

Hunter(Francis W),Hsu(Huai-Ling),Su(Jiechu... Mol Cancer Ther 2015-11-10

...BRCA1 genotype. However, HAP sensitivity was enhanced by suppression of HR (assessed by radiation-induced RAD51 focus fo...

Daly(Mary B),Pilarski(Robert),Axilbund(Jen... J Natl Compr Canc Netw 2015-05-22

...BRCA1/BRCA2, TP53, and PTEN, and recommend approaches to genetic testing/counseling and management strategies in individ...

Rybchenko(L A),Bychkova(A M),Skyban(G V),K... Probl Radiac Med Radiobiol 2015-02-05

Burdened family history of breast and/or ovarian cancer may indicate the mutations carriage in the BRCA1 and BRCA2 genes...

Liu(Liang),Zhou(Weiying),Cheng(Chun-Ting),... Mol Cancer Res 2015-07-22

...BRCA1 axis were observed in primary breast tumor specimens. By downregulating BRCA1, ATM, and MSH2, TGFβ orchestrates DN...

Vos(Janet R),Teixeira(Natalia),van der Kol... Cancer Epidemiol Biomarkers... 2015-07-08

...BRCA1/2 carriers in the Northern Netherlands (N = 1,050). Carrier and general reference populations were: BRCA1/2 carrie...

Abdel-Fatah(Tarek M A),Perry(Christina),Ar... Antioxid Redox Signal 2015-06-30

...BRCA1), and topoisomerase 2 (TOPO2) expression. Multivariate Cox proportional hazards model was used to calculate a DNA ...

Feng(Felix Y),Speers(Corey),Liu(Meilan),Ja... Breast Cancer Res Treat 2015-09-21

...BRCA1 mutational status and that PARP1 activity may serve as a clinically relevant biomarker of response. These studies ...

Rubin(Lisa R),Werner-Lin(Allison),Sagi(Mic... Hum Fertil (Camb) 2015-04-17

Despite research on BRCA1/2 mutation carriers attitudes towards preimplantation genetic diagnosis (PGD), considerably le...

Paul(B T),Blanchard(Z),Ridgway(M),ElShamy(... Oncogene 2015-08-07

...BRCA1-IRIS was silenced in them. We show that BRCA1-IRIS activates two autocrine signaling loops, brain-derived neurotro...

Zhu(B),Yan(K),Li(L),Lin(M),Zhang(S),He(Q),... Oncogene 2015-08-24

...BRCA1 (receptor-associated protein 80-BRCA1) complex for subsequent modulation of HR repair of ICLs induced by mitomycin...

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