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PARP-inhibitors in BRCA-associated pancreatic cancer.

Bhalla(Anshul),Saif(Muhammad Wasif) JOP 2015-05-12

...BRCA1, BRCA2, and PALB2 with chemotherapy which targets the DNA repair defect in these cells, such as platinum based the...

The K898E germline variant in the PP1-binding motif of BRCA1 causes defects i...

Chen(Bert Yu-Hung),Huang(Cheng-Hsiang),Lin... Sci Rep 2015-10-22

...BRCA1 and PP1α. Moreover, while the expression of wild-type BRCA1 in Brca1-deficient cells improved cell survival after ...

Integrative and comparative genomic analysis of HPV-positive and HPV-negative...

Seiwert(Tanguy Y),Zuo(Zhixiang),Keck(Micha... Clin Cancer Res 2015-09-22

...BRCA1/2 mutations, were identified.,The mutational makeup of HPV-positive and HPV-negative HNSCC differs significantly, ...

BRCA1 EXON 11, a CERES (composite regulatory element of splicing) element inv...

Tammaro(Claudia),Raponi(Michela),Wilson(Da... Int J Mol Sci 2015-03-30

...BRCA1 can affect normal pre-mRNA splicing. Here, we investigate the UV c.693G>A, a "silent" change in BRCA1 exon 11, whi...

The BRCA1-interacting protein Abraxas is required for genomic stability and t...

Castillo(Andy),Paul(Atanu),Sun(Baohua),Hua... Cell Rep 2015-08-24

...BRCA1 confer hereditary susceptibility to breast and ovarian cancer. However, somatic mutation of BRCA1 is infrequent in...

An efficient DNA-fueled molecular machine for the discrimination of single-ba...

Song(Tingjie),Xiao(Shiyan),Yao(Dongbao),Hu... Adv Mater 2015-06-08

...BRCA1 in homogeneous solution at room temperature.

Selective inhibitors of nuclear export (SINE) as novel therapeutics for prost...

Mendonca(Janet),Sharma(Anup),Kim(Hae-Soo),... Oncotarget 2015-11-20

...BRCA1 leading to cell cycle arrest and apoptosis. We demonstrate that selective inhibitors of nuclear export (SINE) can ...

Histone deacetylase inhibitor treatment induces 'BRCAness' and synergistic le...

Ha(Kyungsoo),Fiskus(Warren),Choi(Dong Soon... Oncotarget 2015-06-05

...BRCA1, and these tumors are sensitive to treatment with poly(ADP) ribose polymerase inhibitors, a majority of TNBCs lack...

Nipple-sparing mastectomy in BRCA1/2 mutation carriers: an interim analysis a...

Yao(Katharine),Liederbach(Erik),Tang(Rong)... Ann Surg Oncol 2015-09-24

...BRCA1/2 carriers. One hundred and twenty-five (62.2 %) patients had a BRCA1 mutation and 76 (37.8 %) had a BRCA2 mutatio...

Genome instability in blood cells of a BRCA1+ breast cancer family.

Xiao(Fengxia),Kim(Yeong C),Snyder(Carrie),... BMC Cancer 2015-02-24

BRCA1 plays an essential role in maintaining genome stability. Inherited BRCA1 germline mutation (BRCA1+) is a determine...

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