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Genome-wide analysis of loss of heterozygosity in breast infiltrating ductal ...

Ruan(Xiaoyang),Liu(Hongfang),Boardman(Lisa... PLoS One 2015-05-29

...BRCA1 (0/23), BRCA2 (2/29) and TP53 (1/13). Analysis at arm level shows distant normal tissue has low level but non-rand...

Pathway-specific engineered mouse allograft models functionally recapitulate ...

Szabova(Ludmila),Bupp(Sujata),Kamal(Muhaym... PLoS One 2015-05-29

...Brca1 respond to treatment with cisplatin and olaparib, a PARP inhibitor, whereas Brca1-wild type tumors are non-respons...

Risk factors for ovarian cancers with and without microsatellite instability.

Segev(Yakir),Pal(Tuya),Rosen(Barry),McLaug... Int J Gynecol Cancer 2015-02-13

...BRCA1 and BRCA2 mutation status, past oral contraceptive use, and tubal ligation. Similarly, we compared the distributio...

Functional deficiency of NBN, the Nijmegen breakage syndrome protein, in a p....

Schröder-Heurich(Bianca),Bogdanova(Natalia... BMC Cancer 2015-03-09

...BRCA1. Mutations in both genes were already present in the heterozygous state in the patient's germline. HCC1395 cells w...

Establishment of novel cell lines recapitulating the genetic landscape of uve...

Amirouchene-Angelozzi(Nabil),Nemati(Fariba... Mol Oncol 2015-08-19

...BRCA1 associated protein-1) deficiency, a hallmark of aggressive disease. The mTOR pathway was shown to be activated in ...

Altered expression of hypoxia-inducible factor-1α (HIF-1α) and its regulatory...

Wang(Jihan),Ni(Zhaohui),Duan(Zipeng),Wang(... PLoS One 2015-05-11

...BRCA1 → STAT3 ← STAT1 gene pathways and their regulated genes. The data showed that there were 82 differentially express...

No association between BRCA1 immunohistochemical expression and tumor grade, ...

Shawky(Abd El-Aty),El-Hafez(Amal Abd),El-T... Asian Pac J Cancer Prev 2015-05-25

...BRCA1 gene protein. BRCA1 expression was compared to patient's age, tumor histology, grade, stage and OS time. Statistic...

BRCA1 haploinsufficiency leads to altered expression of genes involved in cel...

Feilotter(Harriet E),Michel(Claire),Uy(Pao... PLoS One 2015-02-12

...BRCA1. Using a series of EBV-transformed cell lines, we explored gene expression patterns in cells that were BRCA1 wildt...

Duration of tamoxifen use and the risk of contralateral breast cancer in BRCA...

Gronwald(Jacek),Robidoux(Andre),Kim-Sing(C... Breast Cancer Res Treat 2015-08-18

Women with a mutation in BRCA1 or BRCA2 face a lifetime risk of breast cancer of approximately 80 %. Tamoxifen treatment...

BRCA1 induces major energetic metabolism reprogramming in breast cancer cells...

Privat(Maud),Radosevic-Robin(Nina),Aubel(C... PLoS One 2015-11-06

...BRCA1-mutated breast cancer cell line transfected or not by wild-type BRCA1. This study revealed that BRCA1 induced nume...

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