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Probing structure-function relationships in missense variants in the carboxy-te…

Carvalho(Renato S),Abreu(Renata B V),Velkova… PLoS One 2015-01-15

Germline inactivating variants in BRCA1 lead to a significantly increased risk of breast and ovarian cancers in carriers...

VEGFR3 inhibition chemosensitizes ovarian cancer stemlike cells through down-re…

Lim(Jaeyoung J),Yang(Kun),Taylor-Harding(Bar… Neoplasia 2015-01-23

...BRCA1 and BRCA2. Inhibition of VEGFR3 in ovarian tumor cells was associated with growth arrest. CD133(+) ovarian cancer ...

Breast cancer: major risk factors and recent developments in treatment.

Majeed(Wafa),Aslam(Bilal),Javed(Ijaz),Khaliq… Asian Pac J Cancer Prev 2015-01-06

...BRCA1 and BRCA2 genes. Obesity, hormone therapy and use of alcohol are possible causes and over-expression of leptin in ...

Surface plasmon resonance biosensor for label-free and highly sensitive detecti…

Li(Yahui),Yan(Yurong),Lei(Yaning),Zhao(Dan),… Colloids Surf B Biointerfaces 2015-02-12

...BRCA1 gene related to inherited breast cancer, and the wild-type and mutant-type sequences were successfully discriminat...

Analyzing cell cycle checkpoints in response to ionizing radiation in mammalian…

Wang(Bin) Methods Mol Biol 2015-01-22

...BRCA1, Chk2, and p53. Here we describe a series of assays that are often used to analyze cell cycle checkpoints after IR...

Analysis of BRCA1and BRCA2 large genomic rearrangements in Sri Lankan familial …

De Silva(Sumadee),Tennekoon(Kamani Hemamala)… BMC Res Notes 2015-01-20

Majority of mutations found to date in the BRCA1/BRCA2 genes in breast and/or ovarian cancer families are point mutation...

Genetic testing and familial implications in breast-ovarian cancer families.

Oosterwijk(Jan C),de Vries(Jakob),Mourits(Ma… Maturitas 2015-03-30

...BRCA1 and BRCA2 has become incorporated in the diagnostic procedure of patients with breast and/or ovarian cancer. Since...

A multi-institutional study on the association between BRCA1/BRCA2 mutational s…

Seong(Moon-Woo),Kim(Kyu Hyung),Chung(Il Yong… Breast Cancer Res Treat 2015-08-18

...BRCA1/2 mutation carriers and 57.1 % of BRCA1 mutation carriers. Conversely, two-thirds of TNBC patients carried BRCA1/2...

Rare key functional domain missense substitutions in MRE11A, RAD50, and NBN con…

Damiola(Francesca),Pertesi(Maroulio),Oliver(… Breast Cancer Res 2015-04-16

...BRCA1, BRCA2, and CHEK2, and then assessed by logistic regression.,Re-analysis of our ATM, BRCA1, and BRCA2 mutation scr...

VGLL1 expression is associated with a triple-negative basal-like phenotype in b…

Castilla(María Ángeles),López-García(María Á… Endocr Relat Cancer 2015-02-09

...BRCA1-associated breast carcinomas on tissue microarrays. RNA-seq data from The Cancer Genome Atlas (TCGA) was used to c...

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